Biocompatible and biodegradable polymers for diagnostic and therapeutic radioisotope delivery
OwnerUrs Hafeli, Sandra Rudershausen +2inventors
InventorsUrs Hafeli, Sandra Rudershausen, Joachim Teller, Cordula Gruttner
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Abstract
This invention relates to biocompatible and biodegradable polymers which are able to bind diagnostic and therapeutic radioisotopes, and the therapeutic use of the same as well as the synthesis of such polymers. It further relates to the preparation of functional implants from these materials, including nanospheres, microspheres, liposomes, micelles, coatings, films, fibers, and foils.
Claims20
A shaped material for delivery of a radionuclide comprised of a biocompatible compound for fixation of the radionuclide, said biocompatible compound represented by the chemical formula:
- (M)(L)j(Ch)k+1
- wherein j is the number 0, 1 or 2;
- k is the number 0, 1 or 2;
- M is a polymeric matrix;
- Ch is a chelator;
- and L is a linker possessing covalent bonds to said polymeric matrix and said chelator;
- and a radionuclide chelated to the biocompatible compound.
A microspheric composition comprised of a compound shaped as a microsphere represented by the following chemical formula:
- (M)(L)j(Ch)k+1
- wherein j is the number 0, 1 or 2;
- k is the number 0, 1 or 2;
- M is a polymeric matrix;
- Ch is a chelator for chelating a radioisotope;
- and L is a linker possessing covalent bonds to said polymeric matrix and said chelator;
- said microsphere having a diameter ranging from about 0.0005 to about 0.05 mm.
A method of treating a tumor, comprising implanting a biocompatible compound in or around the tumor, said biocompatible material including a therapeutically effective amount of a radionuclide chelated to said biocompatible compound.
Dependencies are inferred from the claim text.