Synthesis of calcium phosphates by mechano-chemical process
AssigneeEtex Corporation
InventorsAliassghar Tofighi, Christian Rey
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Abstract
A low crystallinity calcium phosphate powder is prepared by mechanically grinding a calcium phosphate solid under grinding forces local heating sufficient to mechanically alloy the calcium phosphate solid and reduce the crystalline domains of the calcium phosphate solid to less than about 100 nm. The method is useful for making any calcium phosphate material by solid-solid mixing and high energy grinding.
Claims40
A method of forming a low crystallinity calcium phosphate powder, comprising:
- high energy grinding a crystalline calcium phosphate solid under forces sufficient to mechanically alloy the calcium phosphate solid and reduce the crystalline domains of the calcium phosphate solid to less than about 100 nm.
A single-component, calcium phosphate self-setting cement, comprising:
- a calcium phosphate powder consisting essentially of a single calcium phosphate source and having an average crystalline domain size of less than about 100 nm;
- and
- a carrier fluid in an amount sufficient to form a malleable paste,
- characterized in that the paste hardens at body temperature in less than 30 minutes.
A calcium phosphate self-setting cement, comprising:
- a calcium phosphate solid and a second solid selected from the group consisting of a calcium source, a phosphate source and a calcium phosphate source, wherein the calcium phosphate solid and the second solid in combination have a calcium to phosphorus atomic ratio in the range of 1:1 to 2:1, and wherein the calcium phosphate solid and the second solid have an average crystalline domain size of less than about 100 nm;
- and
- a carrier fluid in an amount sufficient to form a malleable paste,
- characterized in that the paste hardens at body temperature in less than 30 minutes.
A method of making amorphous dicalcium phosphate dihydrate comprising:
- high energy milling a crystalline dicalcium phosphate dihydrate powder for a time sufficient to reduce the average size of the crystalline domains to less than 100 nm.
Dependencies are inferred from the claim text.