Percutaneous device for site specific delivery and method of use
OwnerCary S. Kaufman, Leslie Jacobsoninventors
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Abstract
The invention is a percutaneous delivery device for the delivery of a diagnostic or therapeutic agent or a physical insult to a specific location in the body. The device comprises an inner member with a preformed delivery portion that can at least partially encircle a target tissue region of interest and an outer member through which the inner member is inserted for targeting to the site of interest. The percutaneous device allows for the delivery of agents or insults from the periphery towards the center of the tumor without passage directly through the tumor or contact with the tumor.
Claims30
A percutaneous delivery device comprising:
- an inner member comprising a first end and a second end wherein the first end comprises a preformed delivery portion and the second end comprises a coupler for coupling the inner member to a delivery source;
- and
- an outer sheath comprising an inner diameter, a first end and a second end, wherein the inner diameter of the sheath is sufficiently large to allow for insertion of the inner member into the second end of the outer sheath and the first end of the outer sheath is sufficiently sharp to pierce tissue and contains an opening sufficiently large for passage of the preformed delivery device.
A method for the treatment of cancer comprising:
- localizing a tumor in an individual by a three-dimensional imaging technique,
- inserting a percutaneous delivery device adjacent to the tumor, the percutaneous delivery device comprising an inner member comprising a first end and a second end wherein the first end comprises a preformed delivery portion and the second end comprises a coupler for coupling the inner member to a delivery source and
- an outer sheath comprising an inner diameter, a first end and a second end, wherein the inner diameter of the sheath is sufficiently large to allow for insertion of the inner member into the second end of the outer sheath and the first end of the outer sheath is sufficiently sharp to pierce tissue and contains an opening sufficiently large for passage of the preformed delivery device;
- deploying the inner member to at least partially encircle the tumor with the preformed delivery device;
- delivering an insult or agent to the tumor;
- and
- withdrawing the delivery device into the sheath for repositioning of the percutaneous device.
Dependencies are inferred from the claim text.