An injector system comprising a powered injector including at least a first drive member for pressurizing a fluid within a first syringe and a second drive member for pressurizing fluid within a second syringe, a cradle extending forward of a first opening in the injector through which the first drive member communicates with the interior of the first syringe and a second opening in the injector through which the second drive member communicates with the interior of the second syringe, a first syringe adapter retention mechanism on a forward end of the cradle, a second syringe adapter retention mechanism on a forward end of the cradle, the injector system further including a first adapter for attaching the first syringe to the injector, and a second adapter for attaching the second syringe to the injector, at least the first adapter including a releasable attachment mechanism for releasably attaching the first adapter to the first adapter retention mechanism, the first adapter including a top opening into which the syringe can be loaded, a first retaining member being positioned on one side of the opening and a second retaining member being positioned on a second side of the opening, the first retaining member and the second retaining member abutting the forward facing abutment surface on the first syringe generally symmetrically, each of the first retaining member and the second retaining member includes a flexible, radially inward extending member that flexes radially outward when contacted by the first syringe during loading of the first syringe into the adapter and returns to a radially inward position once the first syringe is loaded within the adapter.