8-Aza-11-deoxy prostaglandin analogues

A compound comprising Formula I:

• 47
• wherein:
• A is —CH2—CH2—, or —CH═CH—;
• B is absent, aryl, or heteroaryl;
• Z is —C(O)OR′, —C(O)NR′R″, —C(O)NSO2R′, —PR′(O)(OR′), —PO(OR′)2, or tetrazol-5-yl;
• wherein R′ and R″ are independently from each other hydrogen or (C1-C6)alkyl;
• m is 1, 2, 3, 4, 5, or 6;
• R1 is alkyl, alkenyl, alkynyl, cycloalkylalkyl, heterocyclylalkyl, aryl, arylalkyl or heteroaryl;
• provided that
• R1 is alkyl, alkenyl, alkynyl, cycloalkylalkyl, heterocyclylalkyl, aryl, arylalkyl or heteroaryl, when B is aryl or heteroaryl and R3, R4, R5 and R6 are not simultaneously hydrogen, and
• R1 is heterocyclylalkyl, aryl, or heteroaryl when B is absent and R3, R4, R5 and R6 are simultaneously hydrogen;
• R2 is hydrogen or (C1-C6)alkyl, (C1-C6)alkenyl, or (C1-C6)alkynyl;
• R3, R4, R5 and R6 are each independently from each other hydrogen or (C1-C6) alkyl;
• or
• R3 and R4, R5 and R6 or R3 and R5 taken together with the atom to which they are attached may form a (C3-C7) alkyl ring;
• or
• a pharmaceutically acceptable salt or solvate, single isomer or racemic or non-racemic mixture of isomers thereof.