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US 2003/0120065 A1Published application
2-aminopyridine and 2-pyridone C-nucleosides
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrian C. Froehler, Arnold J. Gutierrez, Mark D. Matteucci
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Abstract
The present invention provides 2-aminopyridine and 2-pyridone C-nucleosides and oligonucleotides containing the subject nucleosides. The nucleosides are useful in the preparation of the subject oligonucleotides. The oligonucleotides are useful in oligonucleotide-based diagnosis and separation through triplex binding.
Claims14
A composition comprising a compound of the formula:
- 35
- wherein:
- each R1 are independently H or a hydroxy protecting group, or both R1 groups are taken together to form a cyclic hydroxy protecting group;
- R2 is H, F, —OR1, or —OR6;
- R3 is H or —CH3;
- each R4 of formula I and II are independently H or an amine protecting group, or both R4 groups of formula I are taken together to form a cyclic amine protecting group;
- R5 is H, —CH3 or —C≡C—CH3;
- and
- R6 is
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- and salts, solvates, resolved enantiomers and purified diastereomers thereof.
8 more elements
Dependencies are inferred from the claim text.