Cell surface molecule-induced macrophage activation
AssigneeNeurotech S.A.
InventorsWeng Tao, Shou Wong, William F. Hickey, Joseph P. Hammang, E. Edward Baetge
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Abstract
This invention provides cells containing recombinant polynucleotides coding for cell surface molecules that, when expressed in the cell, result in rejection of the cell by the host immune system. The invention also provides methods of using such cells, and capsules for delivery of biologically active molecules to a patient.
Claims5
A recombinant polynucleotide comprising a promoter operably linked with a polynucleotide coding for an immunostimulatory cell surface polypeptide, wherein the immunostimulatory cell surface polypeptide:
- (a) activates phagocytes;
- but
- (b) does not fix complement.
An immunostimulatory cell surface polypeptide, comprising a cell surface Fc expressed in reverse orientation to the cell surface.
Dependencies are inferred from the claim text.