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US 2003/0120056 A1Published application
TIE ligand homologues
OwnerAudrey Goddard, Paul J. Godowski +1inventors
InventorsAudrey Goddard, Paul J. Godowski, Austin L. Gurney
Life of this patent
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Abstract
The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL2, NL3 and FLS139, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
Claims20
An isolated nucleic acid molecule encoding a mammalian TIE ligand,
- (a) selected from the group consisting of human NL-2 (SEQ. ID. NO:
- 2), human NL-3 (SEQ. ID. NO:
- 4), human FLS139 (SEQ. ID. NO:
- 6), and homologs thereof in a non-human mammalian species;
- or
- (b) a biologically active functional derivative thereof,
- provided that if the functional derivative is an amino acid sequence variant, it has at least about 90% sequence identify with the fibrinogen-like domain of a human NL-2, human NL-3 or human FLS139 ligand.
4 more elements
An isolated mammalian TIE ligand,
- (a) selected from the group consisting of human NL-2 (SEQ. ID. NO:
- 2), human NL-3 (SEQ. ID NO:
- 4), human FLS139 (SEQ. ID. NO:
- 6), and homologs thereof in a non-human mammalian species;
- or
- (b) a biologically active functional derivative thereof,
- provided that if the functional derivative is an amino acid sequence variant, it has at least about 90% sequence identity with the fibrinogen-like region of a human NL-2, human NL-3 or human FLS139 ligand.
4 more elements
A method for imaging the presence of antiogenesis, which comprises administering to a patient a detectably labeled TIE ligand or antibody agonist of a TIE receptor, and monitoring angiogenesis.
Dependencies are inferred from the claim text.