Nucleic acid molecules encoding CASPR/p190
AssigneeSugen, Inc.
InventorElior Peles
Life of this patent
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Abstract
The 190 kDa Contactin ASsociated PRotein (CASPR/p190) is identified and is implicated as the bridge between contactin and intracellular second messenger systems for the signal caused by the binding of the carboxy anhydrase domain of RPTPβ to contactin and resulting in neurite growth, differentiation or survival. Mammalian CASPR/p190 cDNAs and proteins are described, including those from human and rat. In addition, particular domains of the proteins are characterized.
Claims15
An isolated nucleic acid molecule having a nucleotide sequence that:
- (a) encodes the amino acid sequence SEQ ID NO:2;
- (b) encodes the amino acid sequence SEQ ID NO:4;
- or
- (c) is the complement of the nucleotide sequence of (a) or (b).
A nucleic acid molecule which comprises (a) a nucleotide sequence that encodes a polypeptide having the amino acid sequence shown in SEQ ID NO:2 from amino acid residues 40-168, 199-330, 362-486, 544-576, 582-739, 809-938, 961-985, 1031-1077, 1083-1218, 1282-1306, or 1328-1369;
- or (b) the complement of the nucleotide sequence of (a).
A nucleic acid molecule which comprises (a) a nucleotide sequence that encodes a p190 polypeptide lacking at least one domain which has an amino acid sequence shown in SEQ ID NO:2 from amino acid residues 40-168, 199-330, 362-486, 544-576, 582-739, 809-938, 961-985, 1031-1077, 1083-1218, 1282-1306, or 1328-1369;
- or (b) the complement of the nucleotide sequence of (a).
Dependencies are inferred from the claim text.