Non-selective cation channel
OwnerGuenter Schultz, Timothy Plant +3inventors
InventorsGuenter Schultz, Timothy Plant, Rainer Strotmann, Christian Harteneck, Karin Nunnenmacher
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OwnerGuenter Schultz, Timothy Plant +3inventors
InventorsGuenter Schultz, Timothy Plant, Rainer Strotmann, Christian Harteneck, Karin Nunnenmacher
Estimating the term…
The present invention relates to nucleic acids which code for the non-selective cation channel OTRPC4 as well as polypeptides which are coded by said nucleic acids. The invention further relates to hosts or host cells which express said polypeptide and processes for finding blockers, activators and modulators of said OTRPC4 cation channels. The invention includes blockers, activators and modulators of said OTRPC4 cation channels and pharmaceutical compositions containing said blockers, activators and modulators. In addition, the invention relates to non-human mammals which contain OTRPC4 either as a transgene, an inactivated gene (knock-out) or modified gene (knock-in).
Nucleic acid, characterised in that it codes for the non-selective cation channel OTRPC4 or for a fragment, a functional variant, an allelic variant or a subunit, or variants of said nucleic acid on the basis of the degenerative code or a nucleic acid which is able to hybridise with said nucleic acid.
6 Nucleic acid according to one of claims 1 to 5, characterised in that it codes for a functional variant of the non-selective cation channel OTRPC4.
Nucleic acid, characterised in that it contains the sequence
Nucleic acid, characterised in that it has the sequence
Nucleic acid, characterised in that it contains the sequence
Nucleic acid, characterised in that it has the sequence
Nucleic acid, characterised in that it comprises the sequence
Nucleic acid, characterised in that it has the sequence
Nucleic acid, characterised in that it contains the sequence
Nucleic acid, characterised in that it has the sequence
Use of a modulator, activator, or inhibitor of OTRPC4 for the regulation of the osmolarity of body fluids.
Pharmaceuticall composition comprising a modulator, activator, or inhibitor of OTRPC4, and a pharmaceutically acceptable carrier, excipient, or diluent.
Dependencies are inferred from the claim text.