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US 2003/0120034 A1Published application
Contrast media for angiography
AssigneeThe University of North Carolina at Chapel Hill
InventorsDon A. Gabriel, Laura J. Melton
Life of this patent
Estimating the term…
Abstract
The present invention provides basic ionic contrast agents that have anticoagulant activity. The contrast media incorporate a lysine or arginine group or derivative, and have a free amino or guanidino group. Methods of using the contrast media are also disclosed.
Claims17
A compound of the formula:
- 21
- wherein:
- R1 is selected from the group consisting of alkyl and alkyl substituted with hydroxy or alkoxy;
- R2, R3 and R4 are each independently selected from the group consisting of hydrogen and alkyl;
- R5 and R6 are each independently selected from the group consisting of hydrogen, alkyl and hydroxyalky,
- n is from 1 to 3;
- Z is —A—NHCH3, or when R1 is hydroxy or alkoxy substituted alkyl and/or when R3 is loweralkyl, or Z is hydroxy-C2-5-alkylamino;
- A is:
- 22
- wherein
- R7 is H or alkyl;
- R8 is H, alkyl, or alkyl substituted by hydroxy or alkoxy;
- or together R7 and R8 form a propylene or hydroxypropylene ring;
- m is O or 1;
- R9 and R10 are each independently H or alkyl;
- or R9 and R10 together form C4-C8 alkylene which is unsubstituted or substituted from one to three times with alkyl or hydroxy;
- R11 is amino or guanidino;
- o is from two to six;
- or a physiologically acceptable salt thereof.
16 more elements
A compound of the formula:
- 23
- wherein:
- R1 is selected from the group consisting of alkyl and alkyl substituted with hydroxy or alkoxy;
- R2 is selected from the group consisting of hydrogen and alkyl;
- R5 and R6 are each independently is selected from the group consisting of hydrogen, alkyl and hydroxyalky,
- R9 and R10 are each independently H or alkyl;
- or R9 and R10 together form C4-C8 alkylene which is unsubstituted or substituted from one to three times with alkyl or hydroxy;
- R11 is amino or guanidino;
- o is from two to six;
- or a physiologically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.