Methods for tissue repair using adhesive materials

A kit for effecting tissue repair, comprising an adhesive composition comprised of

• (a) a hydrophilic polymer;
• (b) a crosslinkable component A having m nucleophilic groups, wherein m≧2;
• (c) a crosslinkable component B having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧2 and m+n>4;
• and
• wherein each of components A and B is biocompatible and nonimmunogenic and crosslinking of the adhesive composition results in a biocompatible, nonimmunogenic, crosslinked matrix.

A pretreated surgically acceptable patch for use in the repair of herniated tissue comprising a surgically acceptable patch and an adhesive composition comprised of

• (a) a hydrophilic polymer;
• (b) a crosslinkable component A having m nucleophilic groups, wherein m≧2;
• (c) a crosslinkable component B having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧2 and m+n>4;
• and
• wherein each of components A and B is biocompatible and crosslinking of the adhesive composition upon contact with moisture results in a biocompatible, crosslinked matrix.