Chondrogenesis promoters and indolin-2-one derivatives
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsHidetomo Kitamura, Atsuhiko Kato, Toru Esaki
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Abstract
A chondrogenesis promoter comprising as an active ingredient a compound represented by general formula (I) or a salt thereof: 1 wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, etc.; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, an acyl group, an aryl group, a heterocyclic group, etc.; R3 represents a lower alkyl group, a cycloalkyl group, an aryl group, a heterocyclic group, etc.; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, etc.; X and Y represent —CH2—, —NH— or —O—; and n represents an integer of 0-4.
Claims18
A chondrogenesis promoter comprising as an active ingredient a compound represented by general formula (I) or a salt thereof:
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- wherein
- R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group with an optional substituent;
- R2 represents a hydrogen atom, a lower alkyl group with an optional substituent, a lower alkenyl group with an optional substituent, a lower alkynyl group with an optional substituent, a lower alkoxy group with an optional substituent, an acyl group with an optional substituent, an aryl group with an optional substituent or a heterocyclic group with an optional substituent;
- R3 represents a lower alkyl group with an optional substituent, a cycloalkyl group with an optional substituent, an aryl group with an optional substituent or a heterocyclic group with an optional substituent;
- R4 represents a hydrogen atom, a lower alkyl group with an optional substituent, an aryl group with an optional substituent, a heterocyclic group with an optional substituent, —OR5, —SR5 or —NR6R7 wherein R5, R6 and R7 may be the same or different and each represents a hydrogen atom, a lower alkyl group with an optional substituent, a cycloalkyl group with an optional substituent, an aryl group with an optional substituent, a heterocyclic group with an optional substituent, a lower alkoxy group or an amino group with an optional substituent, and R6 and R7 may together form a group represented by —(CH2)m— or —(CH2)1NR8(CH2)k— wherein k, l and m each represent an integer of 1-8 and R8 represents a hydrogen atom or a lower alkyl group;
- X and Y may be the same or different and each represents —CH2—, —NH— or —O—, and n represents an integer of 0-4.
An indolin-2-one derivative represented by the following general formula (IV):
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- wherein R12 represents a lower alkyl group substituted at the same carbon with two lower alkoxy groups which is substituted with 1-5 halogen atoms, or a salt thereof.
Dependencies are inferred from the claim text.