Polyamide modulators of COX2 transcription
OwnerDennis P. Phillion, Barry L. Burnette +4inventors
InventorsDennis P. Phillion, Barry L. Burnette, Barbara A. Schweitzer, Kathleen S. Crowley, James K. Bashkin, Scott S. Woodard
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Abstract
Processes and compositions are provided for regulating COX2 gene expression in a cell. The process includes selecting a polyamide composition comprising N-methyl pyrrole (Py) and N-methyl imidazole (Im) to provide specific binding to DNA at a COX2 gene target site in a cell. The polyamide is then combined with the cell containing the COX2 gene, wherein the polyamide binds to the COX2 gene promoter target site and regulates transcription of the COX2 gene.
Claims18
A process for regulating COX2 gene expression in a cell containing the COX2 gene the process comprising introducing a polyamide into the cell, the polyamide 5 comprising N-methyl pyrrole (Py) and N-methyl imidazole (IM) to provide specific binding to DNA at a COX2 gene promoter target site in a cell, wherein said polyamide binds to the COX2 gene promoter target site and regulates transcription of the COX2 gene.
A polyamide compound for regulating COX2 gene expression comprising N-methyl pyrrole (Py) and N-methyl imidazole (IM), said polyamide compound specifically binding to a COX2 gene promoter region of DNA.
Dependencies are inferred from the claim text.