1,3-Disubstituted-2- thioxo-imidazolidine-4,5-dione derivatives useful in the treatment of atherosclerosis
AssigneeWyeth
InventorsHassan M. Elokdah, Theodore S. Sulkowski
Life of this patent
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Abstract
Antiatherosclerotic compounds of Formula I are provided: 1 wherein: R is lower alkyl, alkenyl, alkynyl, or —O—(CH2)n—COOR′; R′ is lower alkyl; n is an integer of 1-3; Ar is phenyl, or phenyl substituted with one or more of halogen, lower alkyl, alkenyl, alkynyl, alkoxy, perfluoroalkyl, perfluoroalkoxy, or alkylthio; and pharmaceutically acceptable salts thereof.
Claims12
Antiatherosclerotic compounds of Formula I
- 12
- wherein:
- R is lower alkyl, alkenyl, alkynyl, or —O—(CH2)n—COOR′;
- R′ is lower alkyl;
- n is an integer of 1-3;
- Ar is phenyl, or phenyl substituted with one or more of halogen, lower alkyl, alkenyl, alkynyl, alkoxy, perfluoroalkyl, perfluoroalkoxy, or alkylthio;
- and
- pharmaceutically acceptable salts thereof.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of Formula I:
- 13
- wherein:
- R is lower alkyl, alkenyl, alkynyl, or —O—(CH2)n—COOR′;
- R′ is lower alkyl;
- n is an integer of 1-3;
- Ar is phenyl, or phenyl substituted with one or more of halogen, lower alkyl, alkenyl, alkynyl, alkoxy, perfluoroalkyl, perfluoroalkoxy, or alkylthio;
- and
- pharmaceutically acceptable salts thereof.
A method for treating atherosclerosis in a mammal in need thereof, comprising administering to said mammal an anti-atherosclerotic effective amount of a compound of Formula I:
- 14
- wherein:
- R is lower alkyl, alkenyl, alkynyl, or —O—(CH2)n—COOR′;
- R′ is lower alkyl;
- n is an integer of 1-3;
- Ar is phenyl, or phenyl substituted with one or more of halogen, lower alkyl, alkenyl, alkynyl, alkoxy, perfluoroalkyl, perfluoroalkoxy, or alkylthio;
- and
- pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.