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US 2003/0119881 A1Published application
Antivirals
AssigneeMedivir AB
InventorsChrister Salhberg, Rolf Noreen, Marita Hogberg, Per Engelhardt
Life of this patent
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Abstract
Compounds of the formula I: 1 Rx is cyano or bromo; R1 is halo; R2 is C1-C3 alkyl, and pharmaceutically acceptable salts and prodrugs thereof have activity as antiretrovirals.
Claims29
A compound of the formula I:
- 39
- Rx is cyano or bromo;
- R1 is halo;
- R2 is C1-C3 alkyl,
- and pharmaceutically acceptable salts and prodrugs thereof:
2 more elements
25 A compound according to any one of claims 1 to 21 for use in therapy
A method for the preparation of a compound of the Formula I comprising the comprising the Curtius rearrangement of the azide of a compound of the formula:
- 41
- followed by coupling with a compound of the formula
- 42
- and deprotection, wherein R1, R2 and Rx are as defined above and PG is an hydroxy-protecting group.
1 more element
Dependencies are inferred from the claim text.