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OwnerJunya Ishida, Hirofumi Yamamoto +8inventors
InventorsJunya Ishida, Hirofumi Yamamoto, Nobukiyo Konishi, Masataka Morita, Katsuya Nakamura, Susumu Miyata, Takehiro Ochi, Yoshiaki Morita, Eiji Yoshimi, Kanae Kuroda
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A compound of the formula (I), wherein R1 is hydrogen, halogen, carbymoyl, cyano, formuly, or lower alkyl optionally substituted with halogen, amino or a protected amino, R2 is hydrogen, halogen, cyano or lower alkoxy, R3 is phenyl or pyridyl, each of which is substituted with lower alkoxy, and R4 is lower alkoxy; provided that either R1 or R2 is hydrogen, then the other is other than hydrogen, or its salts, which are useful as a medicament.
A compound of the formula (I):
An analgesic agent comprising a selective cyclooxygenase-I inhibitor, a cyclooxygenase-II vs. cyclooxygenase-I IC50 values ratio of which is higher than 30 in a whole blood assay and cyclooxygenase-II IC50 value thereof is higher than 0.2 μM in a whole blood assay.
A method for treating and/or preventing inflammatory conditions, various pains, collagen diseases, autoimmune diseases, various immunity diseases, analgesic, thrombosis, cancer or neurodegerative diseases, which comprises administering an effective amount of a selective cyclooxygenase-I inhibitor,
A use of a selective cyclooxygenase-I inhibitor,
A method for selecting a selective cyclooxygenase-I inhibitor, which lacks gastrointestinal disorders, by assessing whether cyclooxygenase-II vs. cyclooxygenase-I IC50 values ratio is higher than 30 in a whole blood assay and whether the cyclooxygenase-II IC50 value thereof is higher than 0.2 μM in whole blood assay.
Dependencies are inferred from the claim text.