Methods for preparing sodium-hydrogen exchanger type-1 inhibitors

A method of preparing a pharmaceutical composition comprising:

• combining a mixture of acetonitrile and a compound of formula IX′
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• with thionyl chloride to form a mixture comprising a compound of formula X′;
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• evaporating excess thionyl chloride from said mixture to form an evaporated mixture;
• combining said evaporated mixture with guanidine to form a final mixture comprising a compound of formula I′
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• isolating said compound of formula I′ from said final mixture;
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• combining said compound of formula I′, or a pharmaceutically acceptable salt thereof, with a pharmaceutically acceptable vehicle, diluent or carrier, wherein R1 is methylsulfonyl or hydrogen, R2 is hydrogen or a halogen, R3 is hydrogen, R4 is hydrogen or a halogen, or R3 and R4 , together with the carbon atoms to which they are attached, form a six member fully unsaturated ring having one hetero atom that is nitrogen.