Ccr5 modulators benzimidazoles or benzotriazoles

A compound of formula (I):

• 51
• wherein
• A is a 5, 6 or 7 membered ring comprising, respectively, 4, 5 or 6 carbons and one nitrogen which carries a substituent R1, A being either saturated or including one endocyclic double bond;
• X—Y is N═C(R5) or N═N;
• J is N or CR2a;
• K is N or CR2b;
• L is N or CR2c;
• M is N or CR2d;
• provided that no more than 2 of J, K L and M are N;
• R2a, R2b, R2c and R2d are, independently, hydrogen, halo, cyano, nitro, hydroxy, SH, S(O)pR6, NR7R8, SO2NR9R10, CONR11R12, NR13SO2R14, NR15COR16, COR17, CO2R18, NR19CONR20R21, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl, C2-6 alkenyloxy, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkoxy(C1-6)alkyl or heterocyclyl, or phenyl, phenyl(C1-4)alkyl, phenoxy, phenyl(C1-4)alkoxy, heteroaryl, heteroaryl(C1-4)alkyl, heteroaryloxy or heteroaryl(C1-4)alkoxy, wherein any of the foregoing phenyl and heteroaryl moieties are optionally substituted with halo, hydroxy, cyano, C1-4 alkyl or C1-4 alkoxy;
• R1 is C1-10 alkyl, C3-7 cycloalkyl, C3-8 alkenyl or C3-8 alkynyl, each optionally substituted with one or more of:
• halo, hydroxy, cyano, nitro, C1-6 alkoxy (itself optionally substituted by heterocyclyl or CONR62R63), C3-7 cycloalkyl, NR22R23, C(O)R24, NR25SO2R26, NR27C(O)R28, SO2NR29R30, CONR31R32, NR33CONR34R35, S(O)mR64, heterocyclyl, heterocyclyloxy, aryl, aryloxy, heteroaryl, heteroaryloxy, 9H-fluorenyl (optionally substituted with halo, hydroxy, cyano, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, phenyl or phenyl(C1-4)alkyl), 9H-xanthenyl (optionally substituted with halo, hydroxy, cyano, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, phenyl or phenyl(C1-4) alkyl) or dibenzo(a,d)cycloheptatrienyl (optionally substituted with halo, hydroxy, cyano, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, phenyl or phenyl(C1-4)alkyl);
• R3, R3a, R4 and R4a are, independently, hydrogen, C1-6 alkyl (optionally substituted by hydroxy or alkoxy), CO2R36 or CONR37R38 (wherein R36, R37 and R38 are, independently, hydrogen or C1-6 alkyl);
• R5 is hydrogen, C1-6 alkyl (optionally substituted with cyano, hydroxy, C1-4 alkoxy, C3-7 cycloalkyl, COR58, SO2NR58R59, C(O)NR75R76, NR74COR65, NR73SO2R66, NHC(O)NR67R72, NR68R69, SO2R77, C(O)R78, heterocyclyl, phenyl or heteroaryl), C3-6 alkenyl, C3-6 alkynyl, C3-7 cycloalkyl, phenyl, heterocyclyl, heteroaryl, OR79, SR79 , CONR39R40, COR39, NR39R40, (wherein R39 and R40 are, independently, hydrogen, C1-6 alkyl (optionally substituted with C3-7 cycloalkyl, phenyl or heteroaryl), C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, phenyl or heteroaryl;
• and R79 is C1-6 alkyl (optionally substituted with C3-7 cycloalkyl, phenyl or heteroaryl), C3-6 alkenyl, C3-6 alkynyl, C3-7 cycloalkyl, phenyl or heteroaryl), NR70SO2R71 or NR70C(O)R71 (wherein R70, R73 and R74 are, independently, hydrogen, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl or C1-6 cycloalkyl;
• and R71 is C1-6 alkyl, C3-7 cycloalkyl, aryl or heteroaryl);
• R64 is alkyl, cycloalkyl, aryl or heteroaryl;
• R13, R15, R19, R25, R27, R33, are, independently, hydrogen, C1-6 alkyl or phenyl;
• R6, R14 and R26 are, independently, alkyl (optionally substituted by halo, hydroxy, C1-6 alkoxy, C1-6 haloalkoxy or phenyl), phenyl or heteroaryl;
• R7, R8, R9, R10, R11, R12, R16, R17, R18, R20, R21, R22, R23, R24, R28, R29, R30, R31, R32, R34, R35, R58, R59, R67, R68, R69, R72, R75 and R76 are, independently, hydrogen or alkyl (optionally substituted by halo, hydroxy, C1-6 alkoxy, C1-6 haloalkoxy, heterocyclyl, CONR60R61, or phenyl (itself optionally substituted by halo, hydroxy, cyano, C1-4 alkyl or C1-4 alkoxy)), phenyl or heteroaryl;
• unless specified otherwise, the foregoing aryl, phenyl and heteroaryl moieties are optionally substituted with halo, cyano, nitro, hydroxy, S(O)qR41, NR42R43, SO2NR44R45, CONR46R47, NR48SO2R49, NR51, COR52, COR53, CO2R54, NR55CONR56R57, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkoxy(C1-6)alkyl, phenyl, phenyl(C1-4)alkyl, phenoxy, phenylthio, phenyl(C1-4)alkoxy, heteroaryl, heteroaryl(C1-4)alkyl, heteroaryloxy or heteroaryl(C1-4)alkoxy;
• wherein any of the immediately foregoing phenyl and heteroaryl moieties are optionally substituted with halo, hydroxy, cyano, C1-4 alkyl or C1-4 alkoxy;
• R48, R51 and R55 are, independently hydrogen, C1-6 alkyl or phenyl;
• R41, R49, R66 are, independently, alkyl (optionally substituted by halo, hydroxy, C1-6 alkoxy, C1-6 haloalkoxy or phenyl (itself optionally substituted by halo, hydroxy, cyano, C1-4 alkyl or C1-4 alkoxy)), phenyl or heteroaryl;
• R42, R43, R44, R45 , R46, R47, R52, R53, R54, R56, R57, R60, R61, R62, R63 and R65 are, independently, hydrogen or alkyl (optionally substituted by halo, hydroxy, C1-6 alkoxy, C1-6 haloalkoxy or phenyl (itself optionally substituted by halo, hydroxy, cyano, C1-4 alkyl or C1-4 alkoxy)), phenyl or heteroaryl;
• the pairs of substituents:
• R7 and R8, R9 and R10, R11 and R12, R20 and R21, R22 and R23, R29 and R30, R31 and R32, R34 and R35, R37 and R38, R39 and R40, R42 and R43, R44 and R45, R46 and R47, R56 and R57, R58 and R59, R75 and R76, R67 and R72 and R68 and R69 may, independently, join to form a ring and such a ring may also comprise an oxygen, sulphur or nitrogen atom;
• R77 and R78 are, independently, N-linked heterocyclyl;
• where for any of the foregoing heterocyclic groups having a ring —N(H)— moiety, that —N(H)— moiety may be optionally substituted by C1-4 alkyl (itself optionally substituted by hydroxy), C(O)(C1-4 alkyl), C(O)NH(C1-4 alkyl), C(O)N(C1-4alkyl)2or SO2(C1-4 alkyl);
• m, p and q are, independently, 0, 1 or 2;
• a ring nitrogen and/or sulphur atom is optionally oxidised to form an N-oxide and/or an S-oxide;
• or a pharmaceutically acceptable salt thereof.