Farnesyl transferase inhibitors

A compound having the formula (I) or formula (II):

• 67
• wherein:
• R1 is H, lower alkyl, cycloalkylthio, or lower alkylthio, or, together with R2, form —CH2— or —C(CH3)2—;
• each of R2 and R3, independently, is H or lower alkyl;
• R4 is H2 or O;
• R5 is H, or substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkyl lower alkyl, cycloalkenyl, cycloalkenyl lower alkyl, aryl, aryl lower alkyl, heterocyclyl, or heterocyclyl lower alkyl, wherein the substituent is lower alkyl, —O—R10, —S(O)mR10 (where m is 0, 1, or 2), —N(R10) (R11), —N—C(O)—R10, —NH—(SO2)—R10;
• —CO2—R10, —C(O)—N(R10)(R11), or —(SO2)—N(R10) (R11);
• each of R6 and R7, independently, is H, —C(O)NHCHR13CO2R14, or substituted or unsubstituted lower alkyl, cycloalkyl, cycloalkyl lower alkyl, cyloalkenyl, cycloalkenyl lower alkyl, aryl, aryl lower alkyl, heterocyclyl, or heterocyclyl lower alkyl, wherein the substituent is OH, lower alkyl, lower alkoxy, aryloxy, aryl lower alkoxy, —N(R10)(R11), —COOH, —C(O)—N(R10)(R11), or halo;
• or R6 and R7, together, form aryl or heterocyclyl;
• each of R8 and R9, independently, is H, or substituted or unsubstituted lower alkyl, cycloalkyl, cycloalkyl lower alkyl, cyloalkenyl, cycloalkenyl lower alkyl, aryl, aryl lower alkyl, heterocyclyl, or heterocyclyl lower alkyl, wherein the substituent is OH, lower alkyl, lower alkoxy, —N(R10)(R11), —COOH, —C(O)—N(—R10)(R11), or halo;
• or R8 and R9, together, form aryl or heterocyclyl;
• and
• each of R10 and R11, independently, is H, lower alkyl, aryl, aryl lower alkyl, cycloalkyl, cycloalkyl lower alkyl, heterocyclyl, or heterocyclyl lower alkyl;
• R12 is NR9, S, or O;
• R13 is substituted or unsubstituted lower alkyl wherein the substituent is lower alkyl, —OR10, —S(O)mR10 (wherein m is 0, 1, or 2) or —N(R10)(R11);
• and
• R14 is H or lower alkyl;
• or a pharmaceutically acceptable salt thereof.