Heterocycle derivatives and drugs

A compound represented by the following general formula (1):

• 20
• wherein X and Y are same or different and each represents a nitrogen atom or CH;
• R1 represents a hydrogen atom or alkyl;
• A1 and A2 are same or different and each represents (1) a single bond or (2) a divalent aliphatic hydrocarbon group which may be substituted and which may have 1 to 3 unsaturated bonds at any positions (such aliphatic hydrocarbon group may contain one heteroatom selected from the group consisting of —NH—, O and S);
• Q represents (1) a single bond, (2) an optionally substituted 3- to 8-membered cycloalkylene group, (3) an optionally substituted phenylene group or (4) an optionally substituted 4- to 8-membered divalent heterocyclic group;
• R2A, R2C and R2D are same or different and each represents a hydrogen atom, alkyl or phenyl, R2B is a hydrogen atom, alkyl, cyano, nitro or phenyl, or a two nitrogen atoms of a guanidino group are cyclized together with one or two of its substituents R2B, R2C and R2D to form a saturated or unsaturated 5- or 6-membered ring;
• or is taken together as —N(R1)-A1-Q-A2-N(R2A)— to form a 5- to 7-membered ring;
• E represents (1) ethenylene, (2) —NRCO—, (3) —NRCONH—, (4) —CONR—, (5) ethynylene, (6) —NRSO2— or (7) aminoalkylene (in which R represents hydrogen or optionally substituted alkyl);
• R3 represents an optionally substituted phenyl group or heterocyclic group;
• and
• R4 and R5 are (1) same or different and each represents a hydrogen atom, alkyl, alkoxy, aralkyloxy, halogen, nitro, hydroxy, alkoxycarbonyl, —NR6R7, —NR6COR7, —NR6SO2R7, —CONR6R7 (in which R6 and R7 are same or different and each represents a hydrogen atom or alkyl) or (2) when adjacent to each other are taken together to form —O(CH2)nO— (wherein n is an integer of 1 or 2) or —CH═CH—CH═CH—;
• or a salt thereof.