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US 2003/0119847 A1Published application
Heteroaryl derivatives as superior ligands for nociceptin receptor ORL-1
AssigneeSchering Corporation
InventorsDeen Tulshian, Ginny D. Ho, Fay W. Ng
Life of this patent
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Abstract
Novel compounds of the formula 1 wherein R is optionally substituted heteroaryl or 2 R1 is H or C1—C6 alkyl; and R2 and R3 are —CH3, —OCH3 or halo; or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositions therefore, and the use of said compounds in the treatment of pain, anxiety, cough, asthma, depression and alcohol abuse are disclosed.
Claims15
A compound represented by the formula
- 31
- or pharmaceutically acceptable salts thereof, wherein
- R is R4-heteroaryl or
- 32
- R′ is H or C1—C6 alkyl;
- R2 and R3 are independently selected from the group consisting of —CH3, —OCH3, fluoro, chloro, bromo and iodo;
- R4 is 1 to 4 substituents independently selected from the group consisting of H, halo, (C1—C6) alkyl, —CN, —CF3, —OCF3, —(CH2)n—OR5, —(CH2)n—NR5R6, —(CH2)n—NHSO2R5, —(CH2)n—NH(CH2)2NR5R6, —(CH2)n—NHC(O)NR5R7, —(CH2)n—N H(H2)2OR5 and 1 -piperazinyl;
- n is 0, 1, 2 or3;
- R5 and R6 are independently selected from the group consisting of H and C1—C-3 alkyl;
- and
- R7 is H, C1—C-3 alkyl or amino(C1-C-3)alkyl.
8 more elements
A compound represented by the formula:
- 34
Dependencies are inferred from the claim text.