Novel compounds
AssigneeAstraZeneca AB
InventorsWilliam Brown, Christopher Walpole, Niklas Plobeck
Life of this patent
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Abstract
Compounds of general formula (I), wherein R1 is selected from phenyl, pyridinyl, thiophenyl, furanyl, imidazolyl; each phenyl ring and heteroaromatic ring optionally and independently being further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
Claims20
A compound according to formula I
- 22
- wherein
- R1 is selected from
- (i) phenyl;
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- where each phenyl ring and heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo;
- as well as pharmaceutically acceptable salts thereof and isomers thereof.
A compound according to any of the preceding claims, in form of its hydrochloride, sulfate, tartrate or citrate salts.
Dependencies are inferred from the claim text.