Monocyte chemoattractant protein-1 inhibitor compounds

The use of a compound of the formula (I):

• 18
• wherein
• R1 is independently selected from trifluoromethyl, C1-4alkyl, halo, hydroxy, C1-4alkoxy, C1-4alkanoyl, C1-4alkanoyloxy, carboxy, trifluoromethoxy, amino, cyano, C1-4alkylamino, di(C1-4alkyl)amino, C1-4alkanoylamino, nitro, carbamoyl, C1-4alkoxycarbonyl, thiol, C1-4alkylsulphanyl, C1-4alkylsulphinyl, C1-4alkylsulphonyl, sulphonamido, carbamoylC1-4alkyl, N—(C1-4alkyl)carbamoylC1-4alkyl, N—(C1-4alkyl)2-carbamoyl-C1-4alkyl, hydroxyC1-4alkyl, C1-4alkoxyC1-4alkyl, morpholino, pyrrolidinyl, carboxyC1-4alkylamino, R3 and —OR3 (where R3 is optionally substituted aryl or an optionally substituted 5- or 6-membered heteroaryl ring);
• p is 0-4 and R1 can have the same or different values when p is 2-4 with the proviso that no more than one R1 can be chosen from the group amino, C1-4alkylamino, di(C1-4alkyl)amino, morpholino and pyrrolidinyl;
• T is of the formula
• —(CHR4)m—,
• where R4 is independently selected from hydrogen or C1-4alkyl and m=1-3 and R4 can have different values when m is 2 or 3;
• X is CO2R4, SO3H, cyano, —SO2NHR4 (where R4 is as defined above), —SO2NHAr (where Ar is an optionally substituted phenyl or optionally substituted 5 or 6 membered heteroaryl ring), —CONHR5 (where R5 is H, cyano, C1-4alkyl, OH, —SO2—C1-4alkyl, —SO2CF3, —SO2-phenyl, —(CHR4)r—COOH, (where r is 1-3 and R4 (as defined above) can take different values when r is 2-3)), or X is a group of formula (II)
• 19
• or X represents a group of formula (III)
• 20
• where the groups defined as R4 may have different values within the definition of R4 above;
• A is selected from phenyl, naphthyl, furyl, pyridyl and thienyl;
• R2 is independently selected from trifluoromethyl, C1-4alkyl, halo, hydroxy, CF3O—,
• C1-4alkoxy, C1-4alkanoyl, C1-4alkanoyloxy, amino, cyano, C1-4alkylamino, (C1-4alkyl)2amino, C1-4alkanoylamino, nitro, carboxy, carbamoyl, C1-4alkoxycarbonyl, thiol, C1-4alkylsulphanyl, C1-4 alkylsulphinyl, C1-4alkylsulphonyl, sulphonamido, carbamoylC1-4alkyl, N-(C1-4alkyl)carbamoylC1-4alkyl, N—(C1-4alkyl)2carbamoyl-C1-4alkyl, hydroxyC1-4alkyl, C1-4alkoxyC1-4alkyl or two R2 values together may form a divalent radical of the formula —O(CH2)1-4O— attached to adjacent carbon atoms on ring A;
• q is 0-4 and R2 can have the same or different values when q is 2-4;
• Z is hydrogen, fluoro, chloro, bromo, iodo, methyl, trifluoromethyl, hydroxymethyl, acetyl, carboxyC3-6cycloalkyl or —(CHR4)r—NR6R7 (where r is 0-2, R6 and R7 are independently selected from H and C1-4alkyl or R6 and R7 together with the nitrogen to which they are attached form a 5 or 6 membered non-aromatic ring optionally containing one further heteroatom selected from O, N or S);
• or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof;
• in the manufacture of a medicament for antagonising an MCP-1 mediated effect in a warm-blooded animal.