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US 2003/0119823 A1Published application
Sodium salt of an HIV integrase inhibitor
AssigneeMerck & Co., Inc.
InventorsNeville J. Anthony, Wei Xu, John V. Lepore, Amar J. Mahajan
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Abstract
A sodium salt of Compound A is disclosed, wherein Compound A is of formula: 1 Compound A is an HIV integrase inhibitor useful for preventing or treating HIV infection, for delaying the onset of AIDS, and for treating AIDS.
Claims23
A sodium salt of Compound A, wherein Compound A is of formula:
- 16
A crystalline monosodium salt of Compound A, characterized by crystallographic d-spacings of 12.6, 5.0, and 4.6 angstroms;
- wherein Compound A is of formula:
- 17
A process for preparing a crystalline sodium salt of Compound A, which comprises:
- (A) dissolving Compound A in a solvent to form a solution;
- and
- (B) treating the solution formed in Step A with NaOH to form the crystalline sodium salt of Compound A.
A process for preparing a crystalline sodium salt of Compound A, which comprises:
- (A) dissolving Compound A monoethanolate in a solvent to form a solution;
- and
- (B) treating the solution formed in Step A with NaOH to form the crystalline sodium salt of Compound A.
Dependencies are inferred from the claim text.