Compositions and methods for treating autoimmune disease
AssigneeThe Regents of the University of Michigan
InventorsJoseph Holoshitz, James A. Shayman, Shi-Yu Tan
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Abstract
Methods and compositions are described for treating and diagnosing autoimmune diseases, and in particular for treating and detecting rheumatoid arthritis. Treatment is described with a new class of anti-RA drug, namely compounds that inhibit proliferation and induce apoptosis.
Claims19
A composition, comprising at least one inhibitor of the sphingomyelin signal transduction pathway in combination with DMSO.
A composition, comprising at least one inhibitor of the sphingomyelin signal transduction pathway, selected from the group consisting of methylsphingosine, dimethylsphingosine, (1S,2R)-D-erythro-2-(N-myristoylamino)-phenyl-1-propanol, N-butyldeoxynojirimycin and 2-(2′-amino-3′-methoxyphenyl-oxanaphthalen-4-one) in combination with DMSO.
A method, comprising:
- a) providing:
- i) a subject, and ii) a composition comprising at least one inhibitor of the sphingomyelin signal transduction pathway;
- and
- b) administering said composition to said subject.
Dependencies are inferred from the claim text.