Aqueous compositions containing metronidazole
AssigneeDow Pharmaceutical Sciences, Inc.
InventorsYunik Chang, Gordon J. Dow
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Abstract
An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains a combination of solubility-enhancing agents, one of which is a cyclodextrin such as beta-cyclodextrin and the second is a compound other than a cyclodextrin. Methods of manufacture and therapeutic use of the solution are disclosed.
Claims44
An aqueous solution that is physically stable for at least one week at 5° C. comprising an amphiphilic or lipophilic chemical compound, a first solubility-enhancing agent which is a cyclodextrin, and a second solubility-enhancing agent.
A method for making an aqueous solution of metronidazole greater than 0.75% comprising combining metronidazole, beta-cyclodextrin (BCD), and niacin or niacinamide in water.
A method for the treatment of a dermatologic or mucosal disorder comprising topically applying an effective amount of aqueous solution of metronidazole having a concentration higher than 0.75% w/w to the site of the disorder and permitting the metronidazole to treat the disorder, wherein the solution comprises beta-cyclodextrin (BCD) and niacin or niacinamide.
A kit for the topical treatment of dermatologic or mucosal disorders comprising a container and an aqueous solution of metronidazole, beta-cyclodextrin, and niacin or niacinamide within said container, wherein the concentration of metronidazole in said solution is higher than 0.75%.
Dependencies are inferred from the claim text.