Compositions and methods for stimulating an immune response
OwnerMarianna Foldvari, Maria Baca-Estradainventors
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Abstract
A composition for improving the immune response in a subject is described. The composition includes biphasic lipid vesicles associated with an immunogen. In one embodiment a nucleic acid containing at least one cytosine-guanine (CpG) dinucleotide is associated with the lipid vesicles to achieve a synergistic immune response.
Claims39
A composition for eliciting in a subject an immune response to an immunogen, comprising
- a suspension of biphasic lipid vesicles having a central core compartment containing an oil-in-water emulsion, and
- associated with the vesicles, an immunogen.
A composition for eliciting in a subject an immune response to an immunogen, comprising
- a suspension of biphasic lipid vesicles having a central core compartment containing an oil-in-water emulsion, and
- associated with the vesicles, (i) an immunogen and (ii) an oligonucleotide having at least one cytosine-guanine (CpG) dinucleotide.
A kit for preparation of a composition effective to elicit in a subject an immune response to an immunogen, comprising
- (i) a biphasic lipid vesicle component, said vesicles having a central core compartment containing an oil-in-water emulsion,
- (ii) an immunogen component;
- and
- (iii) an oligonucleotide component, said oligonucleotide having at least one cytosine-guanine (CpG) dinucleotide;
- wherein said components are admixed to form a composition effective to elicit an immune response.
A kit for preparation of a composition effective to elicit in a subject an immune response to an immunogen, comprising
- (i) a biphasic lipid vesicle component, said vesicles having a central core compartment containing an oil-in-water emulsion, said vesicles containing an entrapped immunogen;
- and
- (ii) a CpG oligonucleotide component, said oligonucleotide having at least one cytosine-guanine (CpG) dinucleotide;
- wherein said components are admixed to form a composition effective to elicit an immune response.
A kit for preparation of a composition effective to elicit in a subject an immune response to an immunogen, comprising
- (i) a biphasic lipid vesicle component, said vesicles having a central core compartment containing an oil-in-water emulsion, said vesicles containing an entrapped oligonucleotide having at least one cytosine-guanine (CpG) dinucleotide;
- and
- (ii) an immunogen component;
- wherein said components are admixed to form a composition effective to elicit an immune response.
An improvement in a composition comprised of a biphasic lipid vesicle and an immunogen, comprising
- an oligonucleotide having at least one cytosine-guanine (CpG) dinucleotide, wherein said improvement is effective to enhance the immune response to the immunogen relative to the response obtained by administration of the vesicles and the immunogen in the absence of the oligonucleotide.
A method for enhancing the immune response obtained by administration of a biphasic lipid vesicle entrapped immunogen, comprising
- administering an oligonucleotide having at least one cytosine-guanine (CpG) dinucleotide.
Dependencies are inferred from the claim text.