Antisense modulation of apolipoprotein (A) expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsRosanne M. Crooke, Mark J. Graham
Life of this patent
Estimating the term…
Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for treatment of diseases associated with expression of apolipoprotein(a) are provided.
Claims20
A compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding human apolipoprotein(a), wherein said compound specifically hybridizes with a nucleic acid molecule encoding human apolipoprotein(a) and inhibits the expression of human apolipoprotein(a).
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding human apolipoprotein(a).
Dependencies are inferred from the claim text.