Controlled release compositions for macrolide antimicrobial agents
AssigneeWockhardt Limited
InventorsJaved Hussain, Pankaj Khapra, Arun S. Gosavi
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Abstract
The present invention provides a controlled release pharmaceutical composition of an acid labile, poorly soluble drug having pH dependent solubility profile in aqueous environment. In a preferred embodiment the drug is combined with a practically water insoluble polymer an optimizing agent and optional additives to produce a controlled release of therapeutic agent when compositions is exposed to aqueous environment.
Claims45
A pharmaceutical composition for controlled release of an active agent having antibiotic activity comprising a mixture of a macrolide antibacterial agent, a water insoluble polymer and an optimizing agent.
The process of claim 29, wherein the binder is a water soluble cellulose derivative, polyvinyl pyrrolidone or mixture thereof.
Dependencies are inferred from the claim text.