Novel compounds possessing antibacterial, antifungal or antitumor activity

A method of treating bacterial or fungal infections, wherein the method comprises administration of a therapeutically effective amount of a compound of Formula (I):

• 37
• wherein:
• Z1 and Z2 are independently —NR3— (wherein R3 is hydrogen or alkyl) or —O—;
• R1 and R2 are independently substituted alkyl, substituted aryl, heteroaryl, or substituted heteroaryl provided that at least one of R1 and R2 is a group that can form a pharmaceutically acceptable acid addition salt;
• R3 is hydrogen, alkyl or R3 and R1 or R2 together with the atoms to which they are attached form a heterocyclic ring;
• X2 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkenyl, alkynyl, cycloalkyl or heterocyclic;
• X1 and X3 are independently aryl, substituted aryl, heteroaryl, substituted heteroaryl, or —CHR4, wherein R4 is natural or unnatural amino acid side chain;
• or a pharmaceutically acceptable acid addition salt thereof.

A method of inhibiting topoisomerase, wherein the method comprises administration of a therapeutically effective amount of a compound of Formula (I):

• 38
• wherein:
• Z1 and Z2 are independently —NR3— (wherein R3 is hydrogen or alkyl) or —O—;
• R1 and R2 are independently substituted alkyl, substituted aryl, heteroaryl, or substituted heteroaryl provided that at least one of R1 and R2 is a group that can form a pharmaceutically acceptable acid addition salt;
• R3 is hydrogen, alkyl or R3 and R1 or R2 together with the atoms to which they are attached form a heterocyclic ring;
• X2 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkenyl, alkynyl, cycloalkyl or heterocyclic;
• X1 and X3 are independently aryl, substituted aryl, heteroaryl, substituted heteroaryl, or —CHR4, wherein R4 is natural or unnatural amino acid side chain;
• or a pharmaceutically acceptable acid addition salt thereof.

A method of treating fungal infections, wherein the method comprises administration of a therapeutically effective amount of the following compound:

• 40
• wherein R14 is hydrogen, —CH2CH2CH(CH3)2 or —CH2(C3H5), and wherein X2 is a moiety selected from a group consisting of the following moieties:
• 41
• wherein
• R5 is hydrogen, alkyl or substituted alkyl;
• R8 is hydrogen, alkyl, substituted alkyl, alkoxy or halo;
• R9 is hydrogen, alkyl, substituted alkyl, alkoxy, nitro or halo;
• R10 is hydrogen or alkyl;
• and,
• R11 is hydrogen or alkyl.