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AssigneeMillennium Pharmaceuticals, Inc., a Delaware corporation
InventorAndrew W. Shyjan
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The present invention relates to methods and compositions for the diagnosis, prevention, and treatment of tumor progression in cells involved in human tumors such as melanomas, breast, gastrointestinal, lung, and bone tumors, various types of skin cancers, and other neoplastic conditions such as leukemias and lymphomas. Genes are identified that are differentially expressed in benign (e.g., non-malignant) tumor cells relative to malignant tumor cells exhibiting a high metastatic potential. Genes are also identified via the ability of their gene products to interact with gene products involved in the progression to, and/or aggressiveness of, neoplastic tumor disease states. The genes and gene products identified can be used diagnostically or for therapeutic intervention.
An isolated nucleic acid comprising the nucleotide sequence SEQ ID NO:2 as depicted in FIG. 3, or the nucleotide sequence of a gene or gene fragment contained in the following clone as deposited with the NRRL:
An isolated nucleic acid which encodes the amino acid sequence depicted in FIG. 3 from amino acid residue number 1 to 542, or its complement.
An isolated nucleic acid which hybridizes to an isolated nucleic acid which encodes the amino acid sequence depicted in FIG. 3 from amino acid residue number 1 to 542, or its complement.
An isolated nucleic acid comprising the nucleotide sequence SEQ ID NO:6 as depicted in FIG. 5, or SEQ ID NO:8 as depicted in FIG. 6.
An isolated nucleic acid which encodes the amino acid sequence depicted in FIG. 5 from amino acid residue number 1 to 1497, or its complement.
An isolated nucleic acid which encodes the amino acid sequence depicted in FIG. 6 from amino acid residue number 1 to 1533, or its complement.
An isolated nucleic acid which hybridizes to a nucleic acid that encodes the amino acid sequence depicted in FIG. 5 from amino acid residue number 1 to 1497 (SEQ ID NO:7), or its complement, or the amino acid sequence depicted in FIG. 6 from amino acid residue number 1 to 1533 (SEQ ID NO:9), or its complement.
A method of diagnosing tumor progression in a mammal, said method comprising:
A method for treating tumor progression in a mammal, said method comprising administering to the mammal a compound in an amount effective to increase the level of expression or activity of a gene transcript or gene product of gene 030 in cells exhibiting a tumor progression state, to a level effective to ameliorate symptoms of the tumor progression state.
A method for inhibiting tumor progression in a mammal, said method comprising administering to the mammal a normal allele of a 030 gene so that the normal gene product is expressed, thereby inhibiting tumor progression.
A method for treating tumor progression in a mammal, said method comprising administering to the mammal an effective amount of a 030 gene product.
A method of monitoring the efficacy of a compound in clinical trials for inhibition of tumor progression in a patient, said method comprising obtaining a first sample of tumor tissue cells from the patient;
Dependencies are inferred from the claim text.