Anti-angiogenic and anti-tumor properties of Vascostatin and other nidogen domains
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorRaghuram Kalluri
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Abstract
A protein with anti-angiogenic properties is disclosed.
Claims36
An isolated Vascostatin, wherein Vascostatin is an isolated protein of the C-terminal globular domain of nidogen, or a fragment, analog, derivative or mutant thereof, wherein the protein, fragment, analog, derivative or mutant thereof has anti-angiogenic activity.
An isolated protein of SEQ ID NO:2, or a fragment, analog, derivative or mutant thereof, wherein the protein, fragment, analog, derivative or mutant has anti-angiogenic activity.
An isolated protein or peptide having 90% or greater sequence identity with SEQ ID NO:2, wherein the protein or peptide has anti-angiogenic activity.
An isolated protein or peptide having 75% or greater sequence identity with SEQ ID NO:2, wherein the protein or peptide has anti-angiogenic activity.
An isolated protein or peptide having 51% or greater sequence identity with SEQ ID NO:2 over 28 or more amino acids, wherein the protein or peptide has anti-angiogenic activity.
An isolated polynucleotide having 90% or greater sequence identity with SEQ ID NO:1, wherein the isolated polynucleotide encodes a polypeptide having anti-angiogenic activity.
An isolated polynucleotide having 85% or greater sequence identity with SEQ ID NO:1, wherein the isolated polynucleotide encodes a polypeptide having anti-angiogenic activity.
Dependencies are inferred from the claim text.