Delivery system

A macromolecule comprising a drug moiety a linker moiety and a carrier moiety selected from the groups set forth below:

• 14 # Drug moiety Linker moiety Carrier moiety (methotrexate)4 ((methylamino)- (L)3βARQIKIW- benzoyl-EGβA)4 FQNRRMKWKK- OH doxorubicin succinimido- RQIKIWFQNRR- benzoyl-C MKWKK-OH doxorubicin succinimido- (D-K)(D-K)(D-W)- benzoyl-C (D-K)(D-M)(D-R)- (D-R)(D-N)(D-Q)- (D-F)(D-W)(D-I)- (D-K)(D-I)(D-Q)- (D-R-NH2) paclitaxel 2′-succinimido- RQIKIWFQNRRM- propionoyl-C KWKK-OH N-term paclitaxel 2′-succinimido- RQIKIWFQNRRM- C-term carboxy- propionoyl-GCG KWKK fluorescein βA paclitaxel 2′-succinimido- RQIKIWFQNRRM- propionoyl-C KWKK-NH2 paclitaxel 2′-succinimido- RRMKWKK-NH2 propionoyl-CβA paclitaxel 7-succinimido- RQIKIWFQNRRM- propionoyl-C KWKK-OH podophyllotoxin 4-succinimido- RQIKIWFQNRRM- propionoyl-C KWKK-OH N-term podophyllotoxin 4-succinimido- RQIKIWFQNRRM- C-term biotinamidocaproyl propionoyl-GCG KWKK βA podophyllotoxin 4-succinimido- RQIKIWFQNRRM- propionoyl-C KWKK-NH2 podophyllotoxin 4-succinimido- (D-R)(D-Q)(D-I)- propionoyl-C (D-K)(D-I)(D-W)- (D-F)(D-Q)(D-N)- (D-R)(D-R)(D-M)- (D-K)(D-W)(D-K)- (D-K-NH2) podophyllotoxin 4-succinimido- RRMKWKK-NH2 propionoyl-CβA podophyllotoxin 4-succinimido- (D-R)(D-R)(D-M)- propionoyl-CβA (D-K)(D-W)(D-K)- (D-K-NH2) epipodophyllotoxin 4′-succinimido- RQIKIWFQNRRM- propionoyl-C KWKK-OH epipodophyllotoxin 4′-succinimido- RQIKIWFQNRRM- propionoyl-C KWKK-NH2 epipodophyllotoxin 4′-succinimido- RRMKWKK-NH2 propionoyl-CβA 4′-demethyl 4-succinimido- RQIKIWFQNRRM- epipodophyllotoxin propionoyl-C KWKK-OH etoposide (G2, G3 succinimido- RQIKIWFQNRRM- and 4′) propionoyl-C KWKK-OH roscovotine succinimido- RQIKIWFQNRRM- propionoyl-C KWKK-OH bohemine βA-succinyl-βA RQIKIWFQNRRM- KWKK-OH bohemine succinimido- RQIKIWFQNRRM- propionoyl-C KWKK-OH podophyllotoxin 4-acetyl-C RQIKIWFQNRRM- KWKK-OH podophyllotoxin 4-acetyl-CβA RRMKWKK-NH2 4′-demethyl 4-acetyl-CβA RRMKWKK-NH2 epipodophyllotoxin 4′-demethyl 4-acetyl-C RQIKIWFQNRRM- epipodophyllotoxin KWKK-NH2 podophyllotoxin 4-succinimido- RRMKWKK-NH2 propionoyl-GCβA camptothecin 10-O-succinimido- RQIKIWFQNRRM- propionoyl-C KWKK-NH2 C-term podophyllotoxin 4-succinimido- RRMKWKK propionoyl-C N-term podophyllotoxin 4-succinimido- propionoyl-C N-term epipodophyllotoxin 4′-succinimido- RRMKWKK propionoyl-C C-term camptothecin 10-O-succinimido- propionoyl-C N-term epipodophyllotoxin 4′-succinimido- RRMKWKK propionoyl-C C-term paclitaxel 2′-(succinimido)- propionoyl-C 4′-methoxy- 4-(4″-aminoanilino) RQIKIWFQNRRM- epipodophyllotoxin succinimido- KWKK-NH2 propionoyl-C 4′-methoxy- 4-(4″-aminoanilino) RRMKWKK-NH2 epipodophyllotoxin succinimido- propionoyl-CβA 4′-demethyl- 4-(4″-aminoanilino) RRMKWKK-NH2 epipodophyllotoxin succinimido- propionoyl-CβA