CDDO-compounds and combination therapies thereof
AssigneeBoard of
InventorsMarina Konopleva, Michael Andreeff, Michael B. Sporn
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Abstract
CDDO-compounds in combination with other chemotherapeutic agents induce and potentiate cytotoxicity and apoptosis in cancer cell. One class of chemotherapeutic agents include retinoids. Cancer therapies based on these combination therapies are provided. Also provided are methods to treat graft versus host diseases using the CDDO compounds.
Claims79
A method for inducing cytotoxicity in a cell comprising contacting said cell with a CDDO-compound and a chemotherapeutic agent, wherein the combination of the CDDO-compound with the chemotherapeutic agent is effective in inducing cytotoxicity in said cell.
A method of killing a tumor cell comprising contacting said tumor cell with a CDDO-compound and a chemotherapeutic agent, wherein the combination of said CDDO-compound with said chemotherapeutic agent, induces killing of said tumor cell.
A method of inducing apoptosis in a tumor cell comprising contacting said tumor cell with a CDDO-compound and a chemotherapeutic agent, wherein the combination of said CDDO-compound with said chemotherapeutic agent, induces apoptosis of said tumor cell.
A method of inducing differentiation in a tumor cell comprising contacting said tumor cell with a CDDO-compound and a chemotherapeutic agent, wherein the combination of said CDDO-compound with said chemotherapeutic agent, induces the differentiation of said tumor cell.
A method of treating cancer in a human patient comprising administering a CDDO-compound and a chemotherapeutic agent to said human patient, wherein the combination of said CDDO-compound with said chemotherapeutic agent, is effective to treat said cancer.
A method of potentiating the effect of a chemotherapeutic agent on a tumor cell comprising contacting said tumor cell with a CDDO-compound and the chemotherapeutic agent.
A method of inhibiting growth of a tumor cell comprising contacting said tumor cell with a CDDO-compound and a chemotherapeutic agent.
A method of inducing apoptosis in a lymphoid cell that expresses Bcl-2 comprising contacting said lymphoid cell with a CDDO-compound and an immunosupressive agent.
A method of treating or preventing graft versus host disease in a subject comprising administering to the subject a CDDO-compound in combination with an immunosupressive agent.
Dependencies are inferred from the claim text.