Omega-conopeptides
AssigneeUniversity of Utah Research Foundation
InventorsBaldomero M. Olivera, J. Michael McIntosh, Maren Watkins, James E. Garrett, Ki-Joon Shon, Richard B. Jacobsen, Robert M. Jones, G. Edward Cartier
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Abstract
The invention relates to ω-conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents, as cardiovascular agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
Claims15
An isolated peptide selected from the group consisiting of:
- (a) a peptide set forth in Table 2
- (b) a derivative of the peptide in (a);
- and
- (c) a propeptide set forth in Table 1 .
An isolated nucleic acid encoding an ω-conopeptide propeptide having an amino acid sequence set forth in Table 1.
An isolated conopeptide propeptide having an amino acid sequence set forth in Table 1.
Dependencies are inferred from the claim text.