Stable, nasally, orally or sublingually applicable pharmaceutical preparation
OwnerHelmut Scheidl, Gerhard Hantich +2inventors
InventorsHelmut Scheidl, Gerhard Hantich, Ernst Hesse, Thomas Zapf
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Abstract
A stable, nasally, orally or sublingually applicable pharmaceutical preparation for administering to patients has an aqueous solution of desmopressin as the active agent. Said solution contains an osmoticum and a buffer which maintains the pH-value in the range of 4 to 6, preferably about 5. The buffer is malic acid, preferably in the form of a racemate. Thereby an improved stability of the desmopressin content in the preparation is obtained.
Claims20
A stable pharmaceutical preparation for nasal, oral or sublingual administration to patients in the form of a liquid solution, in particular an aqueous solution of desmopressin as the active substance, this liquid solution containing an osmotic agent and a buffer which maintains the pH within the range 4 to 6, preferably at around 5, characterised in that the buffer used to stabilise the desmopressin is malic acid.
Dependencies are inferred from the claim text.