Pharmaceutical composition comprising factor VII polypeptides and PAI-1 polypeptides
OwnerRasmus Rojkjaerinventor
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Abstract
The present invention relates to a composition comprising factor VII or a factor VII-related polypeptide, and PAI-1 or a PAI-1-related polypeptide, and the use thereof for treating bleeding episodes.
Claims53
A pharmaceutical composition comprising (i) factor VII or a factor VII-related polypeptide, and (ii) PAI-1 or a PAI-1-related polypeptide.
A kit of parts containing a treatment for bleeding episodes comprising
- a) An effective amount of a preparation of factor VII or a factor VII-related polypeptide and a pharmaceutically acceptable carrier in a first-unit dosage form;
- b) An effective amount of a preparation of PAI-1 or a PAI-1-related polypeptide and a pharmaceutically acceptable carrier in a second-unit dosage form;
- and
- c) Container means for containing said first and second dosage forms.
Use of factor VII or a factor VII-related polypeptide in combination with a PAI-1 or a PAI-1-related polypeptide for the manufacture of a medicament for treating bleeding episodes.
A method for treating bleeding episodes in a subject, the method comprising administering to a subject in need thereof a first amount of a preparation comprising factor VII or a factor VII-related polypeptide and a second amount of a preparation comprising PAI-1 or a PAI-1-related polypeptide, wherein the first and second amount together are effective to treat bleedings.
A method for reducing clotting time in a subject, the method comprising administering to a subject in need thereof a first amount of a preparation comprising factor VII or a factor VII-related polypeptide and a second amount of a preparation comprising PAI-1 or a PAI-1-related polypeptide, wherein the first and second amount together are effective to reduce clotting time.
A method to enhance haemostasis in a subject, the method comprising administering to a subject in need thereof a first amount of a preparation comprising factor VII or a factor VII-related polypeptide and a second amount of a preparation comprising PAI-1 or a PAI-1-related polypeptide, wherein the first and second amount together are effective to enhance haemostasis.
A method for prolonging the clot lysis time in a subject, the method comprising administering to a subject in need thereof a first amount of a preparation comprising factor VII or a factor VII-related polypeptide and a second amount of a preparation comprising PAI-1 or a PAI-1-related polypeptide, wherein the first and second amount together are effective to prolong the clot lysis time.
A method for increasing clot strength in a subject, the method comprising administering to a subject in need thereof a first amount of a preparation comprising factor VII or a factor VII-related polypeptide and a second amount of a preparation comprising PAI-1 or a PAI-1-related polypeptide, wherein the first and second amount together are effective to increase clot strength.
A kit containing a treatment for bleeding episodes comprising
- a) An effective amount of factor VII or a factor VII-related polypeptide and an effective amount of PAI-1 or a PAI-1-related polypeptide and a pharmaceutically acceptable carrier in a single-unit dosage form;
- and
- b) Container means for containing said single-unit dosage form.
Dependencies are inferred from the claim text.