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US 2003/0119719 A1Published application
Use of endothelin conjugates in therapy, new endothelin conjugates, agents that contain the latter, and process for their production
OwnerLudger Dinkelborg, Ulrich Speck +2inventors
InventorsLudger Dinkelborg, Ulrich Speck, Christoph-Stephan Hilger, Friedhelm Blume
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Abstract
This invention relates to the use of conjugates that consist of endothelins and active groups for therapy of vascular diseases as well as new endothelin conjugates, agents that contain these compounds and process for their production.
Claims24
Use of the compounds of general formula (I)
- E-Wn (I)
- in which
- E stands for a radical that binds endothelin receptors and is derived from endothelins, endothelin analogs, endothelin derivatives, endothelin partial sequences, and endothelin antagonists, and
- W stands for an active group that is a radionuclide or that is derived from a chemotherapy agent, a complex with a radioactive metal isotope, an antibody, antibody fragment, peptide, carbohydrate, oligonucleotide, PTK blocker, antithrombotic agent, clotting cascade inhibitor, hormone, growth factor inhibitor, pharmaceutical agent, platelet aggregation inhibitor, anti-inflammatory agent, Ca-antagonist, lipid-lowering agent, or an antiproliferative agent, and
- n stands for numbers 1 to 100, preferably 1 to 10, as therapeutic agents.
2 more elements
Compounds of general formula (II)
- E-W1n (II)
- in which
- E stands for a radical that binds endothelin receptors and is derived from endothelins, endothelin analogs, endothelin derivatives, endothelin partial sequences, and endothelin antagonists, and
- W1 stands for an active group that contains a radionuclide of the elements At, Ba, Br, C, F, N, O or P or that is derived from a chemotherapy agent, an antibody, antibody fragment, peptide, carbohydrate, oligonucleotide, PTK blocker, antithrombotic agent, growth factor inhibitor, pharmaceutical agent, hormone, platelet aggregation inhibitor, anti-inflammatory agent, Ca-antagonist, lipid-lowering agent, or an antiproliferative agent, and
- n stands for numbers 1 to 100, preferably 1 to 10.
2 more elements
Dependencies are inferred from the claim text.