Detectable labels, methods of manufacture and use
AssigneeCorning Incorporated
InventorsMatthew J. Dejneka, Joydeep Lahiri, Uwe R. Muller, Cameron W. Tanner, Patrick D. Tepesch
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Abstract
Labels, methods of making labels and methods of using labels are disclosed. The labels can be manufactured using fiber drawing techniques or by shutter masking. The labels can be used for detecting the presence of an analyte in a sample and for detecting interactions of biomolecules.
Claims57
A detectable label comprising a particle doped with at least one rare earth element.
A method of detecting an analyte in a sample comprising placing the sample in contact with a particle doped with at least one rare earth element, the particle including a chemical functional group and a pattern thereon to provide a label for the particle;
- and
- monitoring the sample for the presence or absence of the analyte.
A method of manufacturing an identifiable label for detecting the presence of an analyte in a sample or interaction of biomolecules comprising:
- drawing a fiber having an array of regions of differing optical properties, the array of regions arranged in a manner to identify the fiber;
- and
- contacting the fiber with a chemical functional group selected from the group consisting of a nucleic acid, an antibody, a protein, and an enzyme.
A method of manufacturing an identifiable label for detecting the presence of an analyte in a sample or interaction of biomolecules comprising:
- providing a particle and shutter masking a pattern thereon to provide a unique identification code for the particle;
- and
- contacting the particle with a chemical functional group.
A method of detecting multiple analytes in a sample comprising the steps of:
- providing coded particles, each of the particles having an analyte associated therewith;
- illuminating the particles with a light source;
- obtaining a spectral image of the particles;
- and
- utilizing the spectral image to decode the particles.
Dependencies are inferred from the claim text.