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US 2003/0119188 A1Published application
Novel compounds
OwnerPatrick Camilleri, Anthony John Kirby +2inventors
InventorsPatrick Camilleri, Anthony John Kirby, Christele Perrin, Caroline McGregor
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Abstract
Peptide-based gemini compounds comprising basic amino acid chains linked by at least epsilon amide bond, showing improved DNA transfection properties, are disclosed. Methods for production of the compounds and the uses thereof are also disclosed.
Claims13
A peptide-based gemini compound according to the formula (I):
- 4
- where:
- A1 and A5, which may be the same or different, is a positively charged group formed from two or more basic amino acids wherein the amide bonds linking said basic amino acids include at least one epsilon (ε) amide bond;
- A2/A6CH(NH)CO, which may be the same or different, is derived from an amino acid;
- p and q, which may be the same or different, is 0 or 1;
- X1/X2CH2CH(NH)CO, which may be the same or different, is derived from cysteine (X1/X2=S), serine or threonine (X1/X2=);
- A4/A8CH(NH)CO, which may be the same or different, is derived from serine or threonine;
- Y is a linker group or a disulphide bond when X1 and X2 is each S;
- R1 and R2 are C(10-20) saturated or unsaturated alkyl groups, and
- W and Z are NH, O, CH2 or S;
- or
- a salt thereof.
9 more elements
Dependencies are inferred from the claim text.