Methods and compositions of bioartifical kidney suitable for use in vivo or ex vivo
AssigneeThe Regents of the University of Michigan
InventorH. David Humes
Life of this patent
Estimating the term…
Abstract
A novel cell seeded hollow fiber bioreactor is described as a potential bioartificial kidney. Endothelial cells along with pericyte, vascular smooth muscle, and/or mesangial cells or any mesenchymally derived support cells are seeded along a hollow fiber in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney. Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure.
Claims5
A bioartificial device, comprising a semipermeable surface coated with (i) a layer of nonimmortalized endothelial cells, epithelial cells, or a mixture thereof and (ii) pericyte, vascular smooth muscle or mesangial cells or a mixture thereof,
- wherein one side of said semipermeable surface is in fluid communication with a blood inlet and the other side is in fluid communication with a blood outlet.
Dependencies are inferred from the claim text.