DNA chip and its preparation
OwnerKozo Sato, Koki Nakamura +1inventors
InventorsKozo Sato, Koki Nakamura, Hiroshi Shinoki
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Abstract
An analytical element (typically DNA chip) composed of a solid carrier and a group of nucleotide derivatives or their analogues fixed to the solid carrier via covalent bonding containing a boron-containing ring structure can be favorably prepared by bringing in a liquid phase a group of nucleotide derivatives or their analogues having at one end or its vicinity a boron-containing group or a divalent group reactive to the boron-containing group to produce a boron-containing ring structure into contact with a solid carrier having on its surface a divalent group reactive to the boron-containing group or a boron-containing group, respectively.
Claims12
An element comprising a solid carrier and a group of nucleotide derivatives or their analogues which are fixed to the solid carrier via covalent bonding, in which the covalent bonding contains a boron-containing ring structure.
A method for preparing an element comprising a solid carrier and a group of nucleotide derivatives or their analogues fixed to the solid carrier via covalent bonding containing a boron-containing ring structure, which comprises bringing in a liquid phase a group of nucleotide derivatives or their analogues having at one end thereof or its vicinity a boron-containing group or a divalent group reactive to the boron-containing group to produce a boron-containing ring structure into contact with a solid carrier having thereon a divalent group reactive to the boron-containing group or a boron-containing group, respectively.
Dependencies are inferred from the claim text.