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AssigneeNitto Denko Corporation
InventorsKeisaku Okada, Shuji Senda, Akio Kobayashi, Eiichiro Fukusaki, Takeshi Honda, Itaru Yanagihara, Tsuyoshi Nakanishi
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The present invention provides a method for obtaining an aptamer capable of specifically adsorbing to Verotoxin-1 produced by Enterohemorrhagic Escherichia coli by an in vitro selection method utilizing affinity chromatography, particularly, a method including use of an affinity column immobilizing thereon a peptide having an amino acid sequence of Verotoxin-1, for the affinity chromatography, and a single strand nucleic acid molecule, which is an aptamer capable of specifically adsorbing to Verotoxin-1.
A method for obtaining an aptamer capable of specifically adsorbing to Verotoxin-1 by an in vitro selection method utilizing affinity chromatography, which comprises using a carrier immobilizing thereon a peptide having an amino acid sequence of Verotoxin-1 for the affinity chromatography.
A method for obtaining an aptamer capable of specifically adsorbing to Verotoxin-1 by an in vitro selection method utilizing affinity chromatography, which comprises using an affinity column immobilizing thereon a peptide having an amino acid sequence consisting of 3 to 30 amino acids from the amino acid sequence of Verotoxin-1.
A single strand nucleic acid molecule, which is an aptamer capable of specifically adsorbing to Verotoxin-1 and which has a base sequence of any of the following (a) to (e):
Dependencies are inferred from the claim text.