Process for the preparation of D-pantothenic acid and/or salts thereof
AssigneeDegussa AG
InventorsThomas Hermann, Birgit Witteck, Mechthild Rieping
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Abstract
A process for the preparation of D-pantothenic acid and/or salts thereof or feedstuffs additives comprising these by fermentation of microorganisms of the Enterobacteriaceae family, in particular those which already produce D-pantothenic acid, in which the nucleotide sequence(s) in the microorganisms which code(s) for the hns gene is/are enhanced, in particular over-expressed.
Claims30
A process for the preparation of D-pantothenic acid and/or a salt thereof or a feedstuffs additive comprising this/these compound(s), comprising fermenting at least one microorganism of the Enterobacteriaceae family, in which at least the nucleotide sequence(s) which code(s) for the hns gene is/are enhanced, under conditions suitable for the formation of the hns gene product DNA-binding protein HLP-II.
A process for the preparation of a feedstuffs additive comprising D-pantothenic acid and/or a salt thereof comprising:
- a) separating the biomass and/or a portion of the constituents in an amount of ≧0 to 100% from a fermentation broth obtained by fermenting at least one microorganism of the Enterobacteriaceae family, in which at least the nucleotide sequence(s) which code(s) for the hns gene is/are enhanced, and comprising D-pantothenic acid,
- b) optionally, concentrating the mixture from a), and
- c) converting the mixture into a finely divided powder to produce a a free-flowing animal feedstuffs additive with a particle size distribution of 20 to 2000 μm.
A microorganism of the Enterobacteriaceae family which produces pantothenic acid and in which the hns gene is present in enhanced form.
Dependencies are inferred from the claim text.