Treatment and diagnosis of infections of gram positive cocci
AssigneeNeuTec Pharma PLC
InventorsJames Peter Burnie, Ruth Christine Matthews
Life of this patent
Estimating the term…
Abstract
The present invention provides bacterial and fungal ABC transporter proteins, immunogenic fragments thereof, neutralising agents specific thereto and binding agents specific thereto for therapeutic and diagnostic use, together with diagnostic test methods, methods of same and kits for performing same. Also provided are immunodominant conserved antigens from gram positive staphylococci, together with neutralising and binding agents specific thereto for use in therapy and diagnosis, and methods of same. Also provided are Staphylococcal holomogues of IstA and IstB and immunogenic fragments thereof, and their uses in methods of treatment and diagnosis of the human or animal body.
Claims41
A bacterial or fungal ABC transporter protein or an immunogenic fragment thereof for use in a method of treatment of the human or animal body.
A bacterial or fungal ABC transporter protein or an immunogenic fragment thereof used in the manufacture of a medicament.
A bacterial or fungal ABC transporter protein or an immunogenic fragment thereof according to any one of the preceding claims, the immunogenic fragment comprising an ATP binding site or a part thereof.
A bacterial or fungal ABC transporter protein or an immunogenic fragment thereof according to any one of the preceding claims, the bacterium being an enterococcus and the immunogenic fragment having the sequence of SEQ ID NO:
- 3.
A neutralising agent specific to a bacterial or fungal ABC transporter protein or immunogenic fragment thereof according to any one of the preceding claims.
A method of treatment of the human or animal body comprising treating a patient with a bacterial or fungal ABC transporter protein or an immunogenic fragment thereof or a neutralising agent specific thereto according to any one of the preceding claims.
A bacterial or fungal ABC transporter protein or an immunogenic fragment thereof for use in a method of diagnosis of the human or animal body.
A bacterial or fungal ABC transporter protein or an immunogenic fragment thereof used in method of diagnosis.
A kit of parts for performing a diagnostic test according to any one of claims 28-30.
A Staphylococcal homologue of IstA or IstB or an immunogenic fragment thereof.
Dependencies are inferred from the claim text.