DNA molecules encoding human nuclear receptor proteins
AssigneeMerck & Co., Inc.
InventorFang Chen
Life of this patent
Estimating the term…
Abstract
The present invention discloses the isolation and characterization of cDNA molecules encoding two human nuclear receptor proteins, designated nNR1, nNR2 and/or nNR2-1. Also within the scope of the disclosure are recombinant vectors, recombinant host cells, methods of screening for modulators of nNR1, nNR2 and/or nNR2-1 activity, and production of antibodies against nNR1, nNR2 and/or nNR2-1, or epitopes thereof.
Claims44
A purified DNA molecule encoding a human nNR1 protein wherein said protein comprises the amino acid sequence as follows:
- 9 MSSDDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGLALG THANGLDSPP MFAGAGLGGT PCRKSYEDCA SGIMEDSAIK CEYMLNAIPK RLCLVCGDIA SGYHYGVASC EACKAFFKRT IQGNIEYSCP ATNECEITKR RRKSCQACRF MKCLKVGMLK EGVRLDRVRG GRQKYKRRLD SESSPYLSLQ ISPPAKKPLT KIVSYLLVAE PDKLYAMPPP GMPEGDIKAL TTLCDLADRE LVVIIGWAKH IPGFSSLSLG DQMSLLQSAW MEILILGIVY RSLPYDDKLV YAEDYIMDEE HSRLAGLLEL YRAILQLVRR YKKLKVEKEE FVTLKALALA NSDSMYIEDL EAVQKLQDLL HEALQDYELS QRHEEPWRTG KLLLTLPLLR QTAAKAVQHF YSVKLQGKVP MHKLFLEMLE AKAWARADSL QEWRPLEQVP SPLHRATKRQ HVHFLTPLPP PPSVAWVGTA QAGYHLEVFL PQRAGWPRAA,
A purified DNA molecule encoding a human nNR1 protein wherein said protein consists of the amino acid sequence as follows:
- 10 MSSDDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGLALG THANGLDSPP MFAGAGLGGT PCRKSYEDCA SGIMEDSAIK CEYMLNAIPK RLCLVCGDIA SGYHYGVASC EACKAFFKRT IQGNIEYSCP ATNECEITKR RRKSCQACRF MKCLKVGMLK EGVRLDRVRG GRQKYKRRLD SESSPYLSLQ ISPPAKKPLT KIVSYLLVAE PDKLYAMPPP GMPEGDIKAL TTLCDLADRE LVVIIGWAKH IPGFSSLSLG DQMSLLQSAW MEILILGIVY RSLPYDDKLV YAEDYIMDEE HSRLAGLLEL YRAILQLVRR YKKLKVEKEE FVTLKALALA NSDSMYIEDL EAVQKLQDLL HEALQDYELS QRHEEPWRTG KLLLTLPLLR QTAAKAVQHF YSVKLQGKVP MHKLFLEMLE AKAWARADSL QEWRPLEQVP SPLHRATKRQ HVHFLTPLPP PPSVAWVGTA QAGYHLEVFL PQRAGWPRAA,
A purified DNA molecule encoding a human nNR1 protein wherein said DNA molecule comprises the nucleotide sequence as set forth in SEQ ID NO:1, as follows:
- 11 GAATATGATG ACCCTAATGC AACAATATCT (SEQ ID NO:1) AACATACTAT CCGAGCTTCG GTCATTTGGA AGAACTGCAG ATTTTCCTCC TTCAAAATTA AAGTCAGCTT ATGGAGAACA TGTATGCTAT GTTCTTGATT GCTTCGCTGA AGAAGCATTG AAATATATTG GTTTCACCTG GAAAAGGCCA ATATACCCAG TAGAAGAATT AGAAGAAGAA AGCGTTGCAG AAGATGATGC AGAATTAACA TTAAATAAAG TGGATGAAGA ATTTGTGGAA GAAGAGACAG ATAATGAAGA AAACTTTATT GATCTCAACG TTTTAAAGGC CCAGACATAT CACTTGGATA TGAACGAGAC TGCCAAACAA GAAGATATTT TGGAATCCAC AACAGATGCT GCAGAATGGA GCCTAGAAGT GGAACGTGTA CTACCGCAAC TGAAAGTCAC GATTAGGACT GACAATAAGG ATTGGAGAAT CCATGTTGAC CAAATGCACC AGCACAGAAG TGGAATTGAA TCTGCTCTAA AGGAGACCAA GGGATTTTTG GACAAACTCC ATAATGAAAT TACTAGGACT TTGGAAAAGA TCAGCAGCCG AGAAAAGTAC ATCAACAATC AGCCGGGAGC CCATGGAGCA CTGTCCTCAG AGATGCGCAG GTTAGGCTCA CTGTCTAGGC CAGGCCCACC TTAGTCACTG TGGACTGGCA ATGGAAGCTC TTCCTGGACA CACCTGCCCT AGCCCTCACC CTGGGGTGGA AGAGAAATGA GCTTGGCTTG CAACTCAGAC CATTCCACGG AGGCATCCTC CCCTTCCCTG GGCTGGTGAA TAAAAGTTTC CTGAGGTCAA GGACTTCCTT TTCCCTGCCA AAATGGTGTC CAGAACTTTG AGGCCAGAGG TGATCCAGTG ATTTGGGAGC TGCAGGTCAC ACAGGCTGCT CAGAGGGCTG CTGAACAGGA TGTCCTCGGA CGACAGGCAC CTGGGCTCCA GCTGCGGCTC CTTCATCAAG ACTGAGCCGT CCAGCCCGTC CTCGGGCATA GATGCCCTCA GCCACCACAG CCCCAGTGGC TCGTCCGACG CCAGCGGCGG CTTTGGCCTG GCCCTGGGCA CCCACGCCAA CGGTCTGGAC TCGCCACCCA TGTTTGCAGG CGCCGGGCTG GGAGGCACCC CATGCCGCAA GAGCTAGGAG GACTGTGCCA GCGGCATCAT GGAGGACTCG GCCATCAAGT GCGAGTACAT GCTCAACGCC ATCCCCAAGC GCCTGTGCCT CGTGTGCGGG GACATTGCCT CTGGCTACCA CTACGGCGTG GCCTCCTGCG AGGCTTGCAA GGCCTTCTTC AAGAGGACTA TCCAAGGGAA CATTGAGTAC AGCTGCCCGG CCACCAACGA GTGCGAGATC ACCAAACGGA GGCGCAAGTC CTGCCAGGCC TGCCGCTTCA TGAAATGCCT CAAAGTGGGG ATGCTGAAGG AAGGTGTGCG CCTTGATCGA GTGCGTGGAG GCCGTCAGAA ATACAAGCGA CGGCTGGACT CAGAGAGGAG CCCATACCTG AGCTTACAAA TTTCTCCACC TGCTAAAAAG GGATTGAGGA AGATTGTGTG ATACGTAGTG GTGGCTGAGC CGGACAAGCT CTATGCCATG CCTCCCCCTG GTATGCCTGA GGGGGACATC AAGGCCCTGA CCACTCTCTG TGACCTGGCA GACCGAGAGC TTGTGGTCAT CATTGGCTGG GCCAAGCACA TCCCAGGCTT CTCAAGCCTC TCCCTGGGGG ACCAGATGAG CCTGCTGCAG AGTGCCTGGA TGGAAATCCT CATCCTGGGC ATCGTGTACC GCTCGCTGCC CTACGACGAC AAGCTGGTGT ACGCTGAGGA CTACATCATG GATGAGGAGC ACTCCCGCCT CGCGGGGCTG CTGGAGCTCT ACCGGGCCAT CCTGCAGCTG GTACGCAGGT ACAAGAAGCT CAAGGTGGAG AAGGAGGAGT TTGTGACGCT CAAGGCCCTG GCCCTCGCCA ACTCCGATTC CATGTACATC GAGGATCTAG AGGCTGTCCA GAAGCTGCAG GACCTGCTGC ACGAGGCACT GCAGGACTAC GAGCTGAGCC AGCGCCATGA GGAGCCCTGG AGGACGGGCA AGCTGCTGCT GACACTGCCG CTGCTGCGGC AGACGGCCGC CAAGGCCGTG CAGCACTTCT ATAGCGTCAA ACTGCAGGGC AAAGTGCCCA TGCACAAACT CTTCCTGGAG ATGCTGGAGG CCAAGGCCTG GGCCAGGGCT GACTCCCTTC AGGAGTGGAG GCCACTGGAG CAAGTGCCCT CTCCCCTCCA CCGAGCCACC AAGAGGCAGC ATGTGCATTT CCTAACTCCC TTGCCCCCTC CCCCATCTGT GGCCTGGGTG GGCACTGCTC AGGCTGGATA CCACCTGGAG GTTTTCCTTC CGCAGAGGGC AGGTTGGCCA AGAGCAGCTT AGAGGATCTC CCAAGGATGA AAGAATGTCA AGCCATGATG GAAAATGCCC CTTCCAATCA GCTGCCTTCA CAAGCAGGGA TCAGAGCAAC TCCCCGGGGA TCCCCAATCC ACGCCCTTCT AGTCCAACCC CCCTCAATGA GAGAGGCAGG CAGATCTCAC CCAGCACTAG GACACCAGGA GGCCAGGGAA AGCATCTCTG GCTCACCATG TAACATCTGG CTTGGAGCAA GTGGGTGTTC TGCACACCAG GCAGCTGCAC CTCACTGGAT CTAGTGTTGC TGCGAGTGAC CTCACTTCAG AGCCCCTCTA GCAGAGTGGG GCGGAAGTCC TGATGGTTGG TGTCCATGAG GTGGAAG.
A puified DNA molecule encoding a human nNR1 protein wherein said DNA molecule consists of the nucleotide sequence as set forth in SEQ ID NO:1, as follows:
- 12 GAATATCATG ACCCTAATGC AACAATATCT (SEQ ID NO:1) AACATACTAT CCGAGCTTCG GTCATTTGGA AGAACTGCAG ATTTTCCTCC TTCAAAATTA AAGTCAGGTT ATGGAGAACA TGTATGCTAT GTTCTTGATT GCTTCGCTGA AGAAGCATTG AAATATATTG GTTTCACCTG GAAAAGGCCA ATATACCCAG TAGAAGAATT AGAAGAAGAA AGCGTTGCAG AAGATGATGC AGAATTAACA TTAAATAAAG TGGATGAAGA ATTTGTGGAA GAAGAGACAG ATAATGAAGA AAACTTTATT GATCTCAACG TTTTAAAGGC CCAGACATAT CACTTGGATA TGAACGAGAC TGCCAAACAA GAAGATATTT TGGAATCCAC AACAGATGCT GCAGAATGGA GCCTAGAAGT GGAACGTGTA CTACCGCAAC TGAAAGTCAC GATTAGGACT GACAATAAGG ATTGGAGAAT CCATGTTGAC CAAATGCACC AGCACAGAAG TGGAATTGAA TCTGCTCTAA AGGAGACCAA GGGATTTTTG GACAAACTCC ATAATGAAAT TACTAGGACT TTGGAAAAGA TCAGCAGCCG AGAAAAGTAC ATCAACAATC AGCCGGGAGC CCATGGAGCA CTGTCCTCAG AGATGCGCAG GTTAGGCTCA CTGTCTAGGC CAGGCCCACC TTAGTCACTG TGGACTGGCA ATGGAAGCTC TTCCTGGACA CACCTGCCCT AGCCCTCACC CTGGGGTGGA AGAGAAATGA GCTTGGCTTG CAACTCAGAC CATTCCACGG AGGCATCCTC CCCTTCCCTG GGCTGGTGAA TAAAAGTTTC CTGAGGTCAA GGACTTCCTT TTCCCTGCCA AAATGGTGTC CAGAACTTTG AGGCCAGAGG TGATCCAGTG ATTTGGGAGC TGCAGGTCAC ACAGGCTGCT CAGAGGOCTG CTGAACAGGA TGTCCTCGGA CGACAGGCAC CTGGGCTCCA GCTGCGGCTC CTTCATCAAG ACTGAGCCGT CCAGCCCGTC CTCGGGCATA GATGCCCTCA GCCACCACAG CCCCAGTGGC TCGTCCGACG CCAGCGGCGG CTTTGGCCTG GCCCTGGGCA CCCACGCCAA CGGTCTGGAC TCGCCACCCA TGTTTGCAGG CGCCGGGCTG GGAGGCACCC CATGCCGCAA GAGCTACGAG GACTGTGCCA GCGGCATCAT GGAGGACTCG GCCATCAAGT GCGAGTACAT GCTCAACGCC ATCCCCAAGC GCCTGTGCCT CGTGTGCGGG GACATTGCCT CTGGCTACCA CTACGGCGTG GCCTCCTGCG AGGCTTGCAA GGCCTTCTTC AAGAGGACTA TCCAAGGGAA CATTGAGTAC AGCTGCCCGG CCACCAACGA GTGCGAGATC ACCAAACGGA GGCGCAAGTC CTGCCAGGCC TGCCGCTTCA TGAAATGCCT CAAAGTGGGG ATGCTGAAGG AAGGTGTGCG CCTTGATCGA GTGCGTGGAG GCCGTCAGAA ATACAAGCGA CGGCTGGACT CAGAGAGCAG CCCATACCTG AGCTTACAAA TTTCTCCACC TGCTAAAAAG CCATTGACCA AGATTGTCTC ATACCTACTG GTGGCTGAGC CGGACAAGCT CTATGCCATG CCTCCCCCTG GTATGCCTGA GGGGGACATC AAGGCCCTGA CCACTCTCTG TGACCTGGCA GACCGAGAGC TTCTGGTCAT CATTGGCTGG GCCAAGCACA TCCCAGGCTT CTCAAGCCTC TCCCTGGGGG ACCAGATGAG CCTGCTGCAG AGTGCCTGGA TGGAAATCCT CATCCTGGGC ATCGTGTACC GCTCGCTGCC CTACGACGAC AAGCTGGTGT ACGCTGAGGA CTACATCATG GATOAGGAGC ACTCCCGCCT CGCGGGGCTG CTGGAGCTCT ACCGGGCCAT CCTGCAGCTG GTACGCAGGT ACAAGAAGCT CAAGGTGGAG AAGGAGGAGT TTGTGACGCT CAAGGCCCTG GCCCTCGCCA ACTCCGATTC CATGTACATC GAGGATCTAG AGGCTGTCCA GAAGCTGCAG GACCTGCTGC ACGAGGCACT GCAGGACTAC GAGCTGAGCC AGCGCCATGA GGAGCCCTGG AGGACGGGCA AGCTGCTGCT GACACTGCCG CTGCTGCGGC AGACGGCCGC CAAGGCCGTG CAGCACTTCT ATAGCGTCAA ACTGCAGGGC AAAGTGCCCA TGCACAAACT CTTCCTGGAG ATGCTGGAGG CCAAGGCCTG GGCCAGGGCT GACTCCCTTC AGGAGTGGAG GCCACTGGAG CAAGTGCCCT CTCCCCTCCA CCGAGCCACC AAGAGGCAGC ATGTGCATTT CCTAACTCCC TTGCCCCCTC CCCCATCTGT GGCCTGGGTG GGCACTGCTC AGGCTGGATA CCACCTGGAG GTTTTCCTTC CGCAGAGGGC AGGTTGGCCA AGAGCAGCTT AGAGGATCTC CCAAGGATGA AAGAATGTCA AGCCATGATG GAAAATGCCC CTTCCAATCA GCTGCCTTCA CAAGCAGGGA TCAGAGCAAC TCCCCGGGGA TCCCCAATCC ACGCCCTTCT AGTCCAACCC CCCTCAATGA GAGAGGCAGG CAGATCTCAC CCAGCACTAG GACACCAGGA GGCCAGGGAA AGCATCTCTG GCTCACCATG TAACATCTGG CTTGGAGCAA GTGGGTGTTC TGCACACCAG GCAGCTGCAC CTCACTGGAT CTAGTGTTGC TGCGAGTGAC CTCACTTCAG AGCCCCTCTA GCAGAGTGGG GCGGAAGTCC TGATGGTTGG TGTCCATGAG GTGGAAG.
A purified DNA molecule encoding a human nNR2 protein wherein said protein comprises the amino acid sequence as follows:
- 13 MDSVELCLPE SFSLHYEEEL LCRMSNKDRH SEQ ID NO:4 IDSSCSSFIK TEPSSPASLT DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPNHKLF LEMLEAIKV, as set forth in three-letter abbreviation in.
A purified DNA molecule encoding a human nNR2 protein wherein said protein consists of the amino acid sequence as follows:
- 14 MDSVELCLPE SFSLHYEEEL LCRMSNKDRH SEQ ID NO.4 IDSSCSSFIK TEPSSPASLT DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL QLVKKYKSMK LEKEEFVTLK ATALANSDSM HIEDVEAVQK LQDVLHEALQ DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPNHKLF LEMLEAKV, as set forth in three letter code as.
A purified DNA molecule encoding a human nNR2 protein wherein said DNA molecule comprises the nucleotide sequence as set forth in SEQ ID NO:3, as follows:
- 15 GCGGGCCGCC AGTGTGGTGG AATTCGGCTT (SEQ ID NO:3) GTCACTAGGA GAACATTTGT GTTAATTGCA CTGTGCTCTG TCAAGGAAAC TTTGATTTAT AGCTGGGGTG CACAAATAAT GGTTGCCGGT CCCACATGGA TTCGGTAGAA CTTTGCCTTC CTGAATCTTT TTCCCTGCAC TACGAGGAAG AGCTTCTCTG CAGAATGTCA AACAAAGATC GACACATTGA TTCCAGCTGT TCGTCCTTCA TCAAGACGGA ACCTTCCAGC CCAGCCTCCC TGACGGACAG CGTCAACCAC CACAGCCCTG GTGGCTCTTC AGACGCCAGT GGGAGCTACA GTTCAACCAT GAATGGCCAT CAGAACGGAC TTGACTGGCC ACCTCTCTAC CCTTCTGCTC CTATCCTGGG AGGTAGTGGG CCTGTCAGGA AACTGTATGA TGACTGCTCC AGCACCATTG TTGAAGATCC CCAGACCAAG TGTGAATACA TGCTCAACTC GATGCCCAAG AGACTGTGTT TAGTGTGTGG TGACATCGCT TCTGGGTACC ACTATGGGGT AGCATCATGT GAAGCCTGCA AGGCATTCTT CAAGAGGACA ATTCAAGGCA ATATAGAATA CAGCTGCCCT GCCACGAATG AATGTGAAAT CACAAAGCGC AGACGTAAAT CCTGCCAGGC TTGCCGCTTC ATGAAGTGTT TAAAAGTGGG CATGCTGAAA GAAGGGGTGC GTCTTGACAG AGTACGTGGA GGTCGGCAGA AGTACAAGCG CAGGATAGAT GCGGAGAACA GCCCATACCT GAACCCTCAG CTGGTTCAGC CAGCCAAAAA GCCATATAAC AAGATTGTCT CACATTTGTT GGTGGCTGAA CCGGAGAAGA TCTATGCCAT GCCTGACCCT ACTGTCCCCG ACAGTGACAT CAAAGCCCTC ACTACACTGT GTGACTTGGC CGACCGAGAG TTGGTGGTTA TCATTGGATG GGCGAAGCAT ATTCCAGGCT TCTCCACGCT GTCCCTGGCG GACCAGATGA GCCTTCTGCA GAGTGCTTGG ATGGAAATTT TGATCCTTGG TGTCGTATAC CGGTCTCTTT CATTTGAGGA TGAACTTGTC TATGCAGACG ATTATATAAT GGACGAAGAC CAGTCCAAAT TAGCAGGCCT TCTTGATCTA AATAATGCTA TCCTGCAGCT GGTAAAGAAA TACAAGAGCA TGAAGCTGGA AAAAGAAGAA TTTGTCACCC TCAAAGCTAT AGCTCTTGCT AATTCAGACT CCATGCACAT AGAAGATGTT GAAGCCGTTC AGAAGCTTCA GGATGTCTTA CATGAAGCGC TGCAGGATTA TGAAGCTGGC CAGCACATGG AAGACCCTCG TCGAGCTGGC AAGATCCTGA TGACACTGCC ACTCCTGAGG CAGACCTCTA CCAAGGCCGT GCAGCATTTC TACAACATCA AACTAGAAGG CAAAGTCCCA ATGCACAAAC TTTTTTTGGA AATGTTGGAG GCCAAGGTCT GACTAAAAGC TCCCTGGGCC TTCCCATCCT TCATGTTGAA AAAGGGAAAA TAAACCCAAG AGTGATGTCG AAGAAACTTA GAGTTTAGTT AACAACATCA AAAATCAACA GACTGCACTG ATAATTTAGC AGCAAGACTA TGAAGCAGCT TTCAGATTCC TCCATAGGTT CCTGATGAGT TCTTTCTACT TTCTCCATCA TCTTCTTTCC TCTTTCTTCC CACATTTCTC TTTCTCTTTA TTTTTTCTCC TTTTCTTCTT TCACCTCCCT TATTTCTTTG CTTCTTTCAT TCCTAGTTCC CATTCTCCTT TATTTTCTTC CCGTCTGCCT GCCTTCTTTC TTTTCTTTAC CTACTCTCAT TCCTCTCTTT TCTCATCCTT CCCCTTTTTT CTATATTTGA AATAGCTTTA GTTTAAAAAA AAAAATCCTC CCTTCCCCCT TTCCTTTCCC TTTCTTTCCT TTTTCCCTTT CCTTTTCCCT TTCCTTTCCT TTCCTCTTGA CCTTCTTTCC ATCTTTCTTT TTCTTCCTTC TGCTGCTGAA CTTTTAAAAG AGGTCTCTAA CTGAAGAGAG ATGGAAGCCA GCCCTGCCAA AGGATGGAGA TCCATAATAT GGATGCCAGT GAACTTATTG TGAACCATAC CGTCCCCAAT GACTAAGGAA TCAAAGAGAG AGAACCAACG TTCCTAAAAG TACAGTGCAA CATATACAAA TTGACTGAGT GCAGTATTAG ATTTCATGGG AGCAGCCTCT AATTAGACAA CTTAAGCAAC GTTGCATCGG CTGCTTCTTA TCATTGCTTT TCCATCTAGA TCAGTTACAG CCATTTGATT CCTTAATTGT TTTTTCAAGT CTTCCAGGTA TTTGTTAGTT TAGCTACTAT GTAACTTTTT CAGGGAATAG TTTAAGCTTT ATTCATTCAT GCAATACTAA AGAGAAATAA GAATACTGCA ATTTTGTGCT GGCTTTGAAC AATTACGAAC AATAATGAAG GACAAATGAA TCCTGAAGGA AGATTTTTAA AAATGTTTTG TTTCTTCTTA CAAATGGAGA TTTTTTTGTA CCAGCTTTAC CACTTTTCAG CCATTTATTA ATATGGGAAT TTAACTTACT CAAGCAATAG TTGAAGGGAA GGTGCATATT ATCACGGATG CAATTTATGT TGTGTGCCAG TCTGGTCCCA AACATCAATT TCTTAACATG AGCTCCAGTT TACCTAAATG TTCACTGACA CAAAGGATGA GATTACACCT ACAGTGACTC TGAGTAGTCA CATATATAAG CACTGCACAT GAGATATAGA TCCGTAGAAT TGTCAGGAGT GCACCTCTCT ACTTGGGAGG TACAATTGCC ATATGATTTC TAGCTGCCAT GGTGGTTAGG AATGTGATAC TGCCTGTTTG CAAAGTCACA GACCTTGCCT CAGAAGGAGC TGTGAGCCAG TATTCATTTA AGAGAATTCC ACCACACTGG CGGCCCGCGC TTGAT.
A purified DNA molecule encoding a human nNR2 protein wherein said DNA molecule consists of the nucleotide sequence as set forth in SEQ ID NO:3, as follows:
- 16 GCGGGCCGCC AGTGTGGTGG AATTCGGCTT (SEQ ID NO:3) GTCACTAGGA GAACATTTGT GTTAATTGCA CTGTGCTCTG TCAAGGAAAC TTTGATTTAT AGCTGGGGTG CACAAATAAT GGTTGCCGGT CGCACATGGA TTCGGTAGAA CTTTGCCTTC CTGAATCTTT TTCCCTGCAC TACGAGGAAG AGCTTCTCTG CAGAATGTCA AACAAAGATC GACACATTGA TTCCAGCTGT TCGTCCTTCA TCAAGACGGA ACCTTCCAGC CCAGCCTCCC TGACGGACAG CGTCAACCAC CACAGCCCTG GTGGCTCTTC AGACGCCAGT GGGAGCTACA GTTCAACCAT GAATGGCCAT CAGAACGGAC TTGACTCGCC ACCTCTCTAC CCTTCTGCTC CTATCCTGGG AGGTAGTGGG CCTGTCAGGA AACTGTATGA TGACTGCTCC AGCACCATTG TTGAAGATCC CCAGACCAAG TGTGAATACA TGCTCAACTC GATGCCCAAG AGACTGTGTT TAGTGTGTGG TGACATCGCT TCTGGGTACC ACTATGGGGT AGCATCATGT GAAGCCTGCA AGGCATTCTT CAAGAGGACA ATTCAAGGCA ATATAGAATA CAGCTGCCCT GCCACGAATG AATGTGAAAT CACAAAGCGC AGACGTAAAT CCTGCCAGGC TTGCCGCTTC ATGAAGTGTT TAAAAGTGGG CATGCTGAAA GAAGGGGTGC GTCTTGACAG AGTACGTGGA GGTCGGCAGA AGTACAAGCG CAGGATAGAT GCGGAGAACA GCCCATACCT GAACCCTCAG CTGGTTCAGC CAGCCAAAAA GCCATATAAC AAGATTGTCT CACATTTGTT GGTGGCTGAA CCGGAGAAGA TCTATGCCAT GCCTGACCCT ACTGTCCCCG ACAGTGACAT CAAAGCCCTC ACTACACTGT GTGACTTGGC CGACCGAGAG TTGGTGGTTA TCATTGGATG GGCGAAGCAT ATTCCAGGCT TCTCCACGCT GTCCCTGGCG GACCAGATGA GCCTTCTGCA GAGTGCTTGG ATGGAAATTT TGATCCTTGG TGTCGTATAC CGGTCTCTTT CATTTGAGGA TGAACTTGTC TATGCAGACG ATTATATAAT GGACGAAGAC CAGTCCAAAT TAGCAGGCCT TCTTGATCTA AATAATGCTA TCCTGCAGCT GGTAAAGAAA TACAAGAGCA TGAAGCTGGA AAAAGAAGAA TTTGTCACCC TCAAAGCTAT AGCTCTTGCT AATTCAGACT CCATGCACAT AGAAGATGTT GAAGCCGTTC AGAAGCTTCA GGATGTCTTA CATGAAGCGC TGCAGGATTA TGAAGCTGGC CAGCACATGG AAGACCCTCG TCGAGCTGGC AAGATGCTGA TGACACTGCC ACTCCTGAGG CAGACCTCTA CCAAGGCCGT GCAGCATTTC TACAACATCA AACTAGAAGG CAAAGTCCCA ATGCACAAAC TTTTTTTGGA AATGTTGGAG GCCAAGGTCT GACTAAAAGC TCCCTGGGCC TTCCCATCCT TCATGTTGAA AAAGGGAAAA TAAACCCAAG AGTGATGTCG AAGAAACTTA GAGTTTAGTT AACAACATCA AAAATCAACA GACTGCACTG ATAATTTAGC AGCAAGACTA TGAAGCAGCT TTCAGATTCC TCCATAGGTT CCTGATGAGT TCTTTCTACT TTCTCCATCA TCTTCTTTCC TCTTTCTTCC CACATTTCTC TTTCTCTTTA TTTTTTCTCC TTTTCTTCTT TCACCTCCCT TATTTCTTTG CTTCTTTCAT TCCTAGTTCC CATTCTCCTT TATTTTCTTC CCGTCTGCCT GCCTTCTTTC TTTTCTTTAC CTACTCTCAT TCCTCTCTTT TCTCATCCTT CCCCTTTTTT CTAAATTTGA AATAGCTTTA GTTTAAAAAA AAAAATCCTC CCTTCCCCCT TTCCTTTCCC TTTCTTTCCT TTTTCCCTTT CCTTTTCCCT TTCCTTTCCT TTCCTCTTGA CCTTCTTTCC ATCTTTCTTT TTCTTCCTTC TGCTGCTGAA CTTTTAAAAG AGGTCTCTAA CTGAAGAGAG ATGGAAGCCA GCCCTGCCAA AGGATGGAGA TCCATAATAT GGATGCCAGT GAACTTATTG TGAACCATAC CGTCCCCAAT GACTAAGGAA TCAAAGAGAG AGAACCAACG TTCCTAAAAG TACAGTGCAA CATATACAAA TTGACTGAGT GCAGTATTAG ATTTCATGGG AGCAGCCTCT AATTAGACAA CTTAAGCAAC GTTGCATCGG CTGCTTCTTA TCATTGCTTT TCCATCTAGA TCAGTTACAG CCATTTGATT CCTTAATTGT TTTTTCAAGT CTTCCAGGTA TTTGTTAGTT TAGCTACTAT GTAACTTTTT CAGGGAATAG TTTAAGCTTT ATTCATTCAT GCAATACTAA AGAGAAATAA GAATACTGCA ATTTTGTGCT GGCTTTGAAC AATTACGAAC AATAATGAAG GACAAATGAA TCCTGAAGGA AGATTTTTAA AAATGTTTTG TTTCTTCTTA CAAATGGAGA TTTTTTTGTA CCAGCTTTAC CACTTTTCAG CCATTTATTA ATATGGGAAT TTAACTTACT CAAGCAATAG TTGAAGGGAA GGTGCATATT ATCACGGATG CAATTTATGT TGTGTGCCAG TCTGGTCCCA AACATCAATT TCTTAACATG AGCTCCAGTT TACCTAAATG TTCACTGACA CAAAGGATGA GATTACACCT ACAGTGACTC TGAGTAGTCA CATATATAAG CACTGCACAT GAGATATAGA TCCGTAGAAT TGTCAGGAGT GCACCTCTCT ACTTGGGAGG TACAATTGCC ATATGATTTC TAGCTGCCAT GGTGGTTAGG AATGTGATAC TGCCTGTTTG CAAAGTCACA GACCTTGCCT CAGAAGGAGC TGTGAGCCAG TATTCATTTA AGAGAATTCC ACCACACTGG CGGCCCGCGC TTGAT.
Dependencies are inferred from the claim text.