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US 2003/0119092 A1Published application
Chimeric G protein coupled receptors
AssigneeSRI International
InventorsGeetha Shankar, Jason N. Munning, Juliet V. Spencer
Life of this patent
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Abstract
The present invention provides chimeric GPCRs that display novel downstream signaling properties.
Claims21
A chimeric Edg receptor comprising:
- a) an extracellular domain of a first Edg receptor;
- b) a transmembrane domain of the first Edg receptor, wherein the transmembrane domain is operably linked to the extracellular domain;
- and
- c) a chimeric intracellular domain comprising an intracellular strand of a second Edg receptor, wherein the chimeric intracellular domain is operably linked to the transmembrane domain.
1 more element
A chimeric Edg receptor selected from the group consisting of Edg1/3(ct), Edg 1/3(i3ct), Edg 1/3(i2i3ct), Edg5/3(i3ct) and Edg8/4(ct).
Dependencies are inferred from the claim text.