Methods for controlling peptide solubility, chemically modified peptides, and stable solvent systems for producing same
AssigneeKeraplast Technologies, Ltd.
InventorMark Van Dyke
Life of this patent
Estimating the term…
Abstract
Methods for chemically modifying peptides, preferably keratinaceous feedstocks, to achieve desired solubility characteristics; stable solvent systems for preparing the modified peptides; and, the resulting chemically modified peptides.
Claims97
A method for controlling solubility characteristics of a proteinaceous feedstock, said method comprising:
- providing said proteinaceous feedstock comprising primary reactive sites and secondary reactive sites;
- treating said feedstock to convert at least a fraction of said primary reactive sites to an ionic fraction, producing an ionic proteinaceous feedstock;
- and
- chemically modifying at least a portion of functionalities selected from the group consisting of unreacted primary reactive sites and secondary reactive sites, thereby producing a modified proteinaceous feedstock comprising a polar fraction at a ratio to said ionic fraction;
- and
- controlling said ratio to achieve solubility characteristics comprising an isoelectric band compatible with a selected solvent.
A method for controlling solubility characteristics of a proteinaceous feedstock, said method comprising:
- providing a proteinaceous feedstock comprising primary reactive sites and secondary reactive sites, said primary reactive sites being selected from the group consisting of cystine groups and cysteine groups;
- treating said feedstock to convert at least a fraction of said primary reactive sites to an ionic fraction, producing an ionic proteinaceous feedstock;
- and
- chemically modifying at least a portion of functionalities selected from the group consisting of unreacted primary reactive sites and secondary reactive sites selected from the group consisting of carboxylic acid groups, amine groups, and hydroxyl groups, thereby producing a modified proteinaceous feedstock comprising a polar fraction at a ratio to said ionic fraction;
- and
- controlling said ratio to achieve an isoelectric band compatible with a selected solvent.
A method for controlling solubility characteristics of a keratinaceous feedstock, said method comprising:
- providing a keratinaceous feedstock comprising primary reactive sites and secondary reactive sites, said primary reactive sites being selected from the group consisting of cystine groups and cysteine groups;
- treating said feedstock to convert at least a fraction of said primary reactive sites to an ionic fraction, producing an ionic keratinaceous feedstock;
- and
- chemically modifying at least a portion of functionalities selected from the group consisting of unreacted primary reactive sites and secondary reactive sites selected from the group consisting of carboxylic acid groups, amine groups, and hydroxyl groups, thereby producing a modified keratinaceous feedstock comprising a polar fraction at a ratio to said ionic fraction;
- and
- controlling said ratio to achieve an isoelectric band compatible with a selected solvent.
Modified protein comprising chemically modified functionalities selected from the group consisting of primary reactive sites and secondary reactive sites comprising a polar fraction at a ratio to an ionic fraction, said polar fraction comprising a hydrophobic reactant and said ionic fraction comprising a hydrophylic component, said hydrophobic reactant and said hydrophilic component comprising other than effective crosslinking agents.
Modified keratin peptides comprising chemically modified functionalities selected from the group consisting of primary reactive sites and secondary reactive sites comprising a polar fraction at a ratio to an ionic fraction, said polar fraction comprising a hydrophobic reactant and said ionic fraction comprising a hydrophylic component, said hydrophobic reactant and said hydrophilic component comprising other than effective crosslinking agents.
A stable solution comprising a mutual solvent comprising one or more dissolved hydrophobic reactant(s) having a first solubility parameter and ionic proteinaceous feedstock adapted to have a second solubility parameter substantially the same as said first solubility parameter.
A stable solution comprising a mutual solvent comprising one or more dissolved hydrophobic reactant(s) having a first solubility parameter and ionic keratin feedstock adapted to have a second solubility parameter substantially the same as said first solubility parameter.
A stable solvent system comprising:
- ionic proteinaceous feedstock dissolved in a first solvent, said ionic proteinaceous feedstock comprising an ionic fraction;
- and
- one or more hydrophobic reactant(s) dissolved in a second solvent that is miscible with said first solvent.
A stable solvent system comprising:
- ionic keratinaceous feedstock dissolved in a first solvent, said ionic keratinaceous feedstock comprising an ionic fraction;
- and,
- one or more hydrophobic reactants dissolved in a second solvent that is miscible with said first solvent.
A stable solvent system comprising:
- ionic keratinaceous feedstock dissolved in a first solvent, said ionic keratinaceous feedstock comprising an ionic fraction;
- and,
- one or more organic reactants dissolved in a second solvent that is miscible with said first solvent.
A stable suspension comprising one or more hydrophobic reactant(s) comprising a second solvent suspended in a first solvent comprising ionic proteinaceous feedstock comprising an ionic fraction, wherein said second solvent is immiscible with said first solvent.
A stable suspension comprising an ionic keratinaceous feedstock suspended a first solvent, said stable suspension further comprising one or more dissolved hydrophobic reactant(s) comprising a second solvent, wherein said first solvent is immiscible with said second solvent.
A stable emulsion comprising one or more hydrophobic reactant(s)0 dissolved in a first solvent and emulsified droplets comprising ionic proteinaceous feedstock comprising an ionic fraction in a second solvent that is immiscible with said first solvent.
A stable emulsion comprising ionic proteinaceous feedstock comprising an ionic fraction dissolved in a first solvent and emulsified droplets comprising one or more hydrophobic reactant(s) in a second solvent that is immiscible with said first solvent.
A stable emulsion comprising one or more hydrophobic reactant(s) dissolved in a first solvent and emulsified droplets comprising ionic keratinaceous feedstock comprising an ionic fraction in a second solvent that is immiscible with said first solvent.
A stable emulsion comprising ionic keratinaceous feedstock comprising an ionic fraction dissolved in a first solvent and emulsified droplets comprising one or more hydrophobic reactant(s) in a second solvent that is immiscible with said first solvent.
Dependencies are inferred from the claim text.