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AssigneeThe University of Arkansas for Medical Sciences
InventorsSamuel M. Owens, Frank Ivy Carroll, Philip Abraham
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The present invention provides synthetic immunochemical haptens for the generation of antibodies that are designed to recognize the common molecular features of d-methamphetamine-like abused stimulants with insignificant cross-reactivity to endogenous substrates (e.g. dopamine) or over-the-counter medications (e.g. 1-methamphetamine, pseudoephedrine, phenylpropanolamine and ephedrine). These monoclonal antibodies and their antigen binding fragments are useful in treatment plans for recovering addicts, in emergency room settings for rapidly reversing a drug overdose, in protection of fetuses from drug-abusing pregnant mothers or in a psychiatric setting to reduce the exacerbation of psychotic disorders caused by stimulant drugs.
A monoclonal antibody that specifically recognizes a stimulant drug of abuse or a metabolite thereof, wherein said drug of abuse or its metabolite is selected from the group consisting of d-methamphetamine, d-amphetamine, (+/−) 3,4-methylenedioxymethamphetamine, (+/−) 3,4-methylenedioxyamphetamine and structural-related analogs of these compounds.
An antigen binding fragment that specifically recognizes a stimulant drug of abuse or a metabolite thereof, wherein said drug of abuse or its metabolite is selected from the group consisting of d-methamphetamine, d-amphetamine, (+/−) 3,4-methylenedioxymethamphetamine, (+/−) 3,4-methylenedioxyamphetamine and structural-related analogs of these compounds.
A substituted methamphetamine having the structure
Dependencies are inferred from the claim text.